Carbon nanoparticles (NPs) from the incomplete combustion of a candle were used as matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). The washed carbon soot NPs (WCS NPs, ~48 nm) exhibit higher laser desorption/ionization efficiency and less background compared with other common metal and carbon matrices. WCS NPs present good reproducibility and high sensitivity in analyzing a wide range of molecules in both positive and negative ionization mode in SALDI-MS. The detection limit of glucose is 1 pmol with WCS NPs as matrix. WCS NPs can be used to quantitatively determine urine glucose, visualize latent fingerprint and image it with SALDI-MS. The UV absorption of WCS NPs and MS spectra analyzed with WCS NPs matrix remain the same after 10 months storage, indicating the good stability of WCS NPs as matrix.
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This work was supported by the National Natural Science Foundation of China (No. 21673096).
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Wang, X., Dou, S., Wang, Z. et al. Carbon nanoparticles derived from carbon soot as a matrix for SALDI-MS analysis. Microchim Acta 187, 161 (2020). https://doi.org/10.1007/s00604-020-4142-x
- Washed carbon soot
- Fingerprint imaging