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Microchimica Acta

, 187:126 | Cite as

A screen-printed electrochemical sensing platform surface modified with nanostructured ytterbium oxide nanoplates facilitating the electroanalytical sensing of the analgesic drugs acetaminophen and tramadol

  • Mohamed KhairyEmail author
  • Craig E. Banks
Original Paper
  • 39 Downloads

Abstract

An electrochemical sensing platform based upon screen-printing electrodes (SPEs) modified with nanostructured lanthanide metal oxides facilitate the detection of the widely misused drugs acetaminophen (ACP) and tramadol (TRA). Among the metal oxides examined, Yb2O3 nanoplates (NPs) were found to give rise to an optimal electrochemical response. The electroanalysis of ACP and TRA individually, and within mixtures, was performed using cyclic and differential pulse voltammetry. The ACP and TRA exhibited non-overlapping voltammetric signals at voltages of +0.30 and + 0.67 V (vs. Ag/AgCl; pH 9) using Yb2O3-SPEs. Pharmaceutical dosage forms and spiked human fluids were analyzed in wide linear concentration ranges of 0.25–654 and 0.50–115 μmol.L−1 with limits of detection (LOD) of 55 and 87 nmol.L−1 for ACP and TRA, respectively. The Yb2O3-SPEs offer a sensitive and chemically stable enzyme-free electrochemical platform for ACP and TRA assay.

Graphical abstract

Schematic presentation of one-shot electrochemical analysis of misused drugs, tramadol (TRA) and acetaminophen (ACP) by utilizing ytterbium oxide nanoplates modified screen-printed electrodes (Yb2O3-SPEs). The Yb2O3-SPEs showed interesting responses for ACP and TRA within pharmaceutical formulations and human fluids.

Keywords

Lanthanide metal oxide Hepatotoxicity Nanozyme Drug abuse Hydrothermal Nanoparticles Addiction Opioid Analgesic 

Notes

Acknowledgments

The authors acknowledge funding from a British Council Institutional Link grant and Science and Technology Development Fund in Egypt (STDF) (No. 172726574, Project ID 18435) for the support of this research.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Supplementary material

604_2020_4118_MOESM1_ESM.docx (2.8 mb)
ESM 1 (DOCX 2902 kb)

References

  1. 1.
    Department of Justice, Drug Enforcement Administration (2014) Schedules of controlled substances: placement of tramadol into schedule IV. Fed Regist 79(127):37623–37630Google Scholar
  2. 2.
    Lewis KS, Han NH (1997) Tramadol: a new centrally acting analgesic. Am J Health Syst Pharm 54:643–652CrossRefGoogle Scholar
  3. 3.
    Scott LJ, Perry CM (2000) Tramadol: a review of its use in perioperative pain. Drugs 60(1):139–176CrossRefGoogle Scholar
  4. 4.
    Kelly KR, Pypendop BH, Christe KL (2015) Pharmacokinetics of tramadol following intravenous and oral administration in male rhesus macaques (Macaca Mulatta). J Vet Pharmacol Ther 38(4):375–382CrossRefGoogle Scholar
  5. 5.
    Karen M, Lesley JS (2001) Tramadol/paracetamol. Drugs 63(11):1079–1086Google Scholar
  6. 6.
    Li M, Jing LH (2007) Electrochemical behavior of acetaminophen and its detection on the PANI–MWCNTs composite modified electrode. Electrochim Acta 52:3250–3257CrossRefGoogle Scholar
  7. 7.
    Belal T, Awad T, Clark CR (2009) Determination of paracetamol and tramadol hydrochloride in pharmaceutical mixture using HPLC and GC-MS. J Chromatogr Sci 47:849–854CrossRefGoogle Scholar
  8. 8.
    Zhu T, Ding L, Guo X, Yang L, Wen A (2007) Simultaneous determination of tramadol and acetaminophen in human plasma by LC–ESI–MS. Chromatographia 66:171–178CrossRefGoogle Scholar
  9. 9.
    Sha YF, Shen S, Duan GL (2005) Rapid determination of tramadol in human plasma by headspace solid-phase microextraction and capillary gas chromatography–mass spectrometry. J Pharm Biomed Anal 37:143–147CrossRefGoogle Scholar
  10. 10.
    Li J, Ju H (2006) Simultaneous determination of ethamsylate, tramadol, and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis 27:3467–3474CrossRefGoogle Scholar
  11. 11.
    Kolivoška V, Gál M, Lachmanová Š, Valášek M, Hromadová M, Pospíšil L (2011) Spectroelectrochemical determination of the electron consumption. Anal Chim Acta 697:23–26CrossRefGoogle Scholar
  12. 12.
    Mohamed MA, Atty SA, Salama NN, Banks CE (2017) Highly selective sensing platform utilizing graphene oxide and multiwalled carbon nanotubes for the sensitive determination of tramadol in the presence of co-formulated drugs. Electroanalysis 29:1038–1048CrossRefGoogle Scholar
  13. 13.
    Ruiyi L, Haiyan Z, Zaijun L, Junkang L (2018) Electrochemical determination of acetaminophen using a glassy carbon electrode modified with a hybrid material consisting of graphene aerogel and octadecylamine-functionalized carbon quantum dots. Microchim Acta 185(2):145CrossRefGoogle Scholar
  14. 14.
    Song X, Fu J, Wang J, Li C, Liu Z (2018) Simultaneous voltammetric determination of acetaminophen and dopamine using a glassy carbon electrode modified with copper porphyrin-exfoliated graphene. Microchim Acta 185(8):369CrossRefGoogle Scholar
  15. 15.
    Tavakkoli N, Soltani N, Shahdost-fard F, Ramezani M, Salavati H, Jalali MR (2018) Simultaneous voltammetric sensing of acetaminophen, epinephrine and melatonin using a carbon paste electrode modified with zinc ferrite nanoparticles. Microchim Acta 185(10):479CrossRefGoogle Scholar
  16. 16.
    Garrido EMPJ, Garrido JMPJ, Borges F, Delerue-Matos C (2003) Development of electrochemical methods for determination of tramadol—analytical application to pharmaceutical dosage forms. J Pharm Biomed Anal 32:975–981CrossRefGoogle Scholar
  17. 17.
    Sanghavi BJ, Srivastava AK (2011) Simultaneous voltammetric determination of acetaminophen and tramadol using Dowex50wx2 and gold nanoparticles modified glassy carbon paste electrode. Anal Chim Acta 706:246–254CrossRefGoogle Scholar
  18. 18.
    Ghorbani-Bidkorbeh F, Shahrokhian S, Mohammadi A, Dinarvand R (2010) Simultaneous voltammetric determination of tramadol and acetaminophen using carbon nanoparticles modified glassy carbon electrode. Electrochim Acta 55:2752–2759CrossRefGoogle Scholar
  19. 19.
    Norouzi P, Dinarvand R, Ganjali MR, Meibodi ASE (2007) Application of adsorptive stripping voltammetry for the nano-level detection of tramadol in biological fluids and tablets using fast fourier transform continuous cyclic voltammetry at an Au microelectrode in a flowing system. Anal Lett 40:2252–2270CrossRefGoogle Scholar
  20. 20.
    Babaei A, Taheri AR, Afrasiabi M (2011) A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids. J Braz Chem Soc 22(8):1549–1558CrossRefGoogle Scholar
  21. 21.
    Chitravathi S, Munichandraiah N (2016) Voltammetric determination of paracetamol, tramadol and caffeine using poly(Nile blue) modified glassy carbon electrode. J Electroanal Chem 764:93–103CrossRefGoogle Scholar
  22. 22.
    Mahmoud BG, Khairy M, Rashwan FA, Foster CW, Banks CE (2016) Self-assembly of porous copper oxide hierarchical nanostructures for selective determinations of glucose and ascorbic acid. RSC Adv 6:14474–14482CrossRefGoogle Scholar
  23. 23.
    Shestakov MV, Tikhomirov VK, Kirilenko D, Kuznetsov AS, Chibotaru LF, Baranov AN, Van Tendeloo G, Moshchalkov VV (2011) Quantum cutting in Li (770 nm) and Yb (1000 nm) Co-dopant emission bands by energy transfer from the ZnO nano-crystalline host. Opt Express 19(17):15955–15964CrossRefGoogle Scholar
  24. 24.
    Fricker SP (2006) The therapeutic application of lanthanides. Chem Soc Rev 35:524–533CrossRefGoogle Scholar
  25. 25.
    Ganjali MR, Memari Z, Faridbod F, Dinarvand R, Norouzi P (2008) Sm3+ potentiometric membrane sensor as a probe for determination of some pharmaceutics. Electroanalysis 20(24):2663–2670CrossRefGoogle Scholar
  26. 26.
    Caravan P (2006) Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev 35:512–523CrossRefGoogle Scholar
  27. 27.
    Khairy M, Mahmoud BG, Banks CE (2018) Simultaneous determination of codeine and its co-formulated drugs acetaminophen and caffeine by utilising cerium oxide nanoparticles modified screen-printed electrodes. Sensors Actuators B Chem 259:142–154CrossRefGoogle Scholar
  28. 28.
    Ensafi AA, Noroozi R, Zandi-Atashbar N, Rezaei B (2017) Cerium (IV) oxide decorated on reduced graphene oxide, a selective and sensitive electrochemical sensor for fenitrothion determination. Sensors Actuators B 245:980–987CrossRefGoogle Scholar
  29. 29.
    Neal CJ, Gupta A, Barkam S, Saraf S, Das S, Cho HJ, Seal S (2017) Picomolar detection of hydrogen peroxide using enzyme-free inorganic nanoparticle-based sensor. Sci Rep 7:1324CrossRefGoogle Scholar
  30. 30.
    Jia G, You H, Yang M, Zhang L, Zhang H (2009) Uniform lanthanide orthoborates LnBO3 (Ln = Gd, Nd, Sm, Eu, Tb, and Dy) microplates: general synthesis and luminescence properties. J Phys Chem C 113:16638–16644CrossRefGoogle Scholar
  31. 31.
    Kachoosangi RT, Wildgoose GG, Compton RG (2008) Sensitive adsorptive stripping voltammetric determination of paracetamol at multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode. Anal Chim Acta 618:54–60CrossRefGoogle Scholar
  32. 32.
    Mahmoud BG, Khairy M, Rashwan FA, Banks CE (2017) Simultaneous voltammetric determination of acetaminophen and isoniazid (hepatotoxicity-related drugs) utilizing bismuth oxide nanorod modified screen-printed electrochemical sensing platforms. Anal Chem 89(3):2170–2178CrossRefGoogle Scholar
  33. 33.
    Fan Y, Liu J-H, Lu HT, Zhang Q (2011) Electrochemical behavior and voltammetric determination of paracetamol on Nafion/TiO2-graphene modified glassy carbon electrode. Colloids Surf B 85:289–292CrossRefGoogle Scholar
  34. 34.
    Dong Y, Zhou M, Zhang L (2019) 3D multiporous Co, N co-doped MoO2/MoC nanorods hybrids as improved electrode materials for highly sensitive simultaneous determination of acetaminophen and 4-aminophenol. Electrochim Acta 302:56–64CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of ScienceSohag UniversitySohagEgypt
  2. 2.Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK

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