Microchimica Acta

, 187:126 | Cite as

A screen-printed electrochemical sensing platform surface modified with nanostructured ytterbium oxide nanoplates facilitating the electroanalytical sensing of the analgesic drugs acetaminophen and tramadol

  • Mohamed KhairyEmail author
  • Craig E. Banks
Original Paper


An electrochemical sensing platform based upon screen-printing electrodes (SPEs) modified with nanostructured lanthanide metal oxides facilitate the detection of the widely misused drugs acetaminophen (ACP) and tramadol (TRA). Among the metal oxides examined, Yb2O3 nanoplates (NPs) were found to give rise to an optimal electrochemical response. The electroanalysis of ACP and TRA individually, and within mixtures, was performed using cyclic and differential pulse voltammetry. The ACP and TRA exhibited non-overlapping voltammetric signals at voltages of +0.30 and + 0.67 V (vs. Ag/AgCl; pH 9) using Yb2O3-SPEs. Pharmaceutical dosage forms and spiked human fluids were analyzed in wide linear concentration ranges of 0.25–654 and 0.50–115 μmol.L−1 with limits of detection (LOD) of 55 and 87 nmol.L−1 for ACP and TRA, respectively. The Yb2O3-SPEs offer a sensitive and chemically stable enzyme-free electrochemical platform for ACP and TRA assay.

Graphical abstract

Schematic presentation of one-shot electrochemical analysis of misused drugs, tramadol (TRA) and acetaminophen (ACP) by utilizing ytterbium oxide nanoplates modified screen-printed electrodes (Yb2O3-SPEs). The Yb2O3-SPEs showed interesting responses for ACP and TRA within pharmaceutical formulations and human fluids.


Lanthanide metal oxide Hepatotoxicity Nanozyme Drug abuse Hydrothermal Nanoparticles Addiction Opioid Analgesic 



The authors acknowledge funding from a British Council Institutional Link grant and Science and Technology Development Fund in Egypt (STDF) (No. 172726574, Project ID 18435) for the support of this research.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Supplementary material

604_2020_4118_MOESM1_ESM.docx (2.8 mb)
ESM 1 (DOCX 2902 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of ScienceSohag UniversitySohagEgypt
  2. 2.Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK

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