Microchimica Acta

, 187:123 | Cite as

CuO/Cu composite nanospheres on a TiO2 nanotube array for amperometric sensing of glucose

  • Zhiru Zhou
  • Zanzan Zhu
  • Feiyun Cui
  • Jiahui Shao
  • Hong Susan ZhouEmail author
Original Paper


A non-enzymatic glucose sensor based on the use of CuO-Cu nanospheres placed on a TiO2 nanotube (TNT) array with excellent performance is described. The electrode was fabricated by coating the CuO-Cu nanospheres onto the TNT array through electrochemical deposition. The CuO-Cu nanospheres with a diameter of ~200 nm are well dispersed on the TNT surface, which warrants smooth interaction and a 3D nanostructure with high uniformity. The modified electrode was then used for amperometric determination of glucose in 0.1 M NaOH solution. Figures of merit include (a) a typical working voltage of 0.65 V (vs. Ag/AgCl). (b) a linear range as wide as from 0.2–90 mM, (c) good sensitivity (234 μA mM−1 cm−2), and a 19 nM lower detection limit. The sensor is selective over ascorbic acid (AA), dopamine (DA), uric acid (UA), lactose, sucrose, and fructose.

Graphical abstract


CuO-Cu nanospheres TiO2 nanotube arrays Amperometric sensing Wide analytical range Enzymeless sensing Glucose sensor 



This work was supported by National Science Foundation (CBET-1805514) to HSZ.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Chemical engineeringWorcester Polytechnic InstituteWorcesterUSA
  2. 2.National Cancer Centre SingaporeSingaporeSingapore
  3. 3.School of Environmental Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina

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