Advertisement

A graphite pencil electrode with electrodeposited Pt-CuO for nonenzymatic amperometric sensing of glucose over a wide linear response range

  • 42 Accesses

Abstract

A disposable nonenzymatic glucose sensor was obtained by pulsed electrodeposition of Pt-CuO on a graphite pencil electrode (GPE). The morphology of the modified GPE was studied using SEM, and the chemical composition of the coating was examined by EDAX and XRD. The electrochemical response of the modified GPE was compared with individual copper- and platinum-modified GPEs. The electrodeposition parameters were optimized with respect to the electrocatalytic activity of the deposits towards glucose oxidation. Best operated at a working potential of 0.6 V vs. Ag/AgCl, the sensor has a sensitivity of 2035 μA mM−1 cm−2, a 0.1 μM detection limit and a wide linear response range that extends up to 25 mM. It is highly selective for glucose in the presence of various exogenous and endogenous interfering species. Eventhough the requirement of alkaline medium for sensing is a limitation, easy fabrication procedure, very high sensitivity and selectivity, wide analytical range, and disposable sensor characteristics show potential application towards blood glucose determination.

Schematic representation of the Pt-CuO electrodeposited pencil graphite electrode for the nonenzymatic determination of glucose.

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant unlimited access to the full article PDF.

US$ 39.95

Price includes VAT for USA

Subscribe to journal

Immediate online access to all issues from 2019. Subscription will auto renew annually.

US$ 199

This is the net price. Taxes to be calculated in checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  1. 1.

    Zhao Y, Zhao J, Ma D, Li Y, Hao X, Li L, Yu C, Zhang L, Lu Y, Wang Z (2012) Synthesis, growth mechanism of different cu nanostructures and their application for non-enzymatic glucose sensing. Colloid Surface A 409:105–111

  2. 2.

    Khashan K, Jabir M, Abdulameer F (2018) Preparation and characterization of copper oxide nanoparticles decorated carbon nanoparticles using laser ablation in liquid. J. Phys. Conf. Ser:012100

  3. 3.

    Pagare PK, Torane A (2016) Band gap varied cuprous oxide (cu 2 O) thin films as a tool for glucose sensing. Microchim Acta 183(11):2983–2989

  4. 4.

    Park S, Chung TD, Kim HC (2003) Nonenzymatic glucose detection using mesoporous platinum. Anal Chem 75(13):3046–3049

  5. 5.

    Bai H, Han M, Du Y, Bao J, Dai Z (2010) Facile synthesis of porous tubular palladium nanostructures and their application in a nonenzymatic glucose sensor. Chem Commun 46(10):1739–1741

  6. 6.

    Dhara K, Ramachandran T, Nair BG, Babu TS (2015) Single step synthesis of au–CuO nanoparticles decorated reduced graphene oxide for high performance disposable nonenzymatic glucose sensor. J Electroanal Chem 743:1–9

  7. 7.

    Tang H, Chen J, Yao S, Nie L, Deng G, Kuang Y (2004) Amperometric glucose biosensor based on adsorption of glucose oxidase at platinum nanoparticle-modified carbon nanotube electrode. Anal Biochem 331(1):89–97

  8. 8.

    Lien C-H, Chen J-C, Hu C-C, Wong DS-H (2014) Cathodic deposition of binary nickel-cobalt hydroxide for non-enzymatic glucose sensing. J taiwan inst chem e 45(3):846–851

  9. 9.

    Singh B, Laffir F, McCormac T, Dempsey E (2010) PtAu/C based bimetallic nanocomposites for non-enzymatic electrochemical glucose detection. Sensors Actuators B Chem 150(1):80–92

  10. 10.

    Li X, Yao J, Liu F, He H, Zhou M, Mao N, Xiao P, Zhang Y (2013) Nickel/copper nanoparticles modified TiO2 nanotubes for non-enzymatic glucose biosensors. Sensors Actuators B Chem 181:501–508

  11. 11.

    Suneesh P, Chandhini K, Ramachandran T, Nair BG, Babu TS (2013) Tantalum oxide honeycomb architectures for the development of a non-enzymatic glucose sensor with wide detection range. Biosens Bioelectron 50:472–477

  12. 12.

    Suneesh P, Vargis VS, Ramachandran T, Nair BG, Babu TS (2015) Co–cu alloy nanoparticles decorated TiO2 nanotube arrays for highly sensitive and selective nonenzymatic sensing of glucose. Sensors Actuators B Chem 215:337–344

  13. 13.

    Meng Z, Sheng Q, Zheng J (2012) A sensitive non-enzymatic glucose sensor in alkaline media based on cu/MnO 2-modified glassy carbon electrode. J Iran Chem Soc 9(6):1007–1014

  14. 14.

    Li M, Bo X, Mu Z, Zhang Y, Guo L (2014) Electrodeposition of nickel oxide and platinum nanoparticles on electrochemically reduced graphene oxide film as a nonenzymatic glucose sensor. Sensors Actuators B Chem 192:261–268

  15. 15.

    Noh H-B, Lee K-S, Chandra P, Won M-S, Shim Y-B (2012) Application of a cu–co alloy dendrite on glucose and hydrogen peroxide sensors. Electrochim Acta 61:36–43

  16. 16.

    Wang W, Li Z, Zheng W, Yang J, Zhang H, Wang C (2009) Electrospun palladium (IV)-doped copper oxide composite nanofibers for non-enzymatic glucose sensors. Electrochem Commun 11(9):1811–1814

  17. 17.

    Zheng B, Liu G, Yao A, Xiao Y, Du J, Guo Y, Xiao D, Hu Q, Choi MM (2014) A sensitive AgNPs/CuO nanofibers non-enzymatic glucose sensor based on electrospinning technology. Sensors Actuators B Chem 195:431–438

  18. 18.

    Chinnadayyala SR, Park I, Cho S (2018) Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array. Microchim Acta 185(5):250

  19. 19.

    He C, Wang J, Gao N, He H, Zou K, Ma M, Zhou Y, Cai Z, Chang G, He Y (2019) A gold electrode modified with a gold-graphene oxide nanocomposite for non-enzymatic sensing of glucose at near-neutral pH values. Microchim Acta 186(11):722

  20. 20.

    Tian T, Dong J, Xu J (2016) Direct electrodeposition of highly ordered gold nanotube arrays for use in non-enzymatic amperometric sensing of glucose. Microchim Acta 183(6):1925–1932

  21. 21.

    Dhara K, Mahapatra DR (2018) Electrochemical nonenzymatic sensing of glucose using advanced nanomaterials. Microchim Acta 185(1):49

  22. 22.

    Santhiago M, Kubota LT (2013) A new approach for paper-based analytical devices with electrochemical detection based on graphite pencil electrodes. Sensors Actuators B Chem 177:224–230

  23. 23.

    Chehreh Chelgani S, Rudolph M, Kratzsch R, Sandmann D, Gutzmer J (2016) A review of graphite beneficiation techniques. Miner Process Extr M 37(1):58–68

  24. 24.

    Prasad BB, Kumar D, Madhuri R, Tiwari MP (2011) Ascorbic acid imprinted polymer-modified graphite electrode: a diagnostic sensor for hypovitaminosis C at ultra trace ascorbic acid level. Sensors Actuators B Chem 160(1):418–427

  25. 25.

    Aziz MA, Kawde A-N (2013) Gold nanoparticle-modified graphite pencil electrode for the high-sensitivity detection of hydrazine. Talanta 115:214–221

  26. 26.

    Tang J, Azumi K (2011) Optimization of pulsed electrodeposition of aluminum from AlCl3-1-ethyl-3-methylimidazolium chloride ionic liquid. Electrochim Acta 56(3):1130–1137

  27. 27.

    Dilgin Y, Kızılkaya B, Ertek B, Işık F, Dilgin DG (2012) Electrocatalytic oxidation of sulphide using a pencil graphite electrode modified with hematoxylin. Sensors Actuators B Chem 171:223–229

  28. 28.

    Pourbeyram S, Mehdizadeh K (2016) Nonenzymatic glucose sensor based on disposable pencil graphite electrode modified by copper nanoparticles. J Food Drug Anal 24(4):894–902

  29. 29.

    Babu TS, Ramachandran T, Nair B (2010) Single step modification of copper electrode for the highly sensitive and selective non-enzymatic determination of glucose. Microchim Acta 169(1–2):49–55

  30. 30.

    Wu G-h, Song X-h, Wu Y-F, Chen X-m, Luo F, Chen X (2013) Non-enzymatic electrochemical glucose sensor based on platinum nanoflowers supported on graphene oxide. Talanta 105:379–385

  31. 31.

    Li Y, Huang F, Chen J, Mo T, Li S, Wang F, Feng S, Li Y (2013) A high performance enzyme-free glucose sensor based on the graphene-CuO nanocomposites. Int J Electrochem Sci 8:6332–6342

  32. 32.

    Dhara K, Stanley J, Ramachandran T, Nair BG, S.B. TG (2014) Pt-CuO nanoparticles decorated reduced graphene oxide for the fabrication of highly sensitive non-enzymatic disposable glucose sensor. Sensors Actuators B Chem 195:197–205

  33. 33.

    Gao H, Xiao F, Ching CB, Duan H (2011) One-step electrochemical synthesis of PtNi nanoparticle-graphene nanocomposites for nonenzymatic amperometric glucose detection. ACS Appl Mater Interfaces 3(8):3049–3057

  34. 34.

    Male KB, Hrapovic S, Liu Y, Wang D, Luong JH (2004) Electrochemical detection of carbohydrates using copper nanoparticles and carbon nanotubes. Anal Chim Acta 516(1–2):35–41

Download references

Acknowledgements

Authors gratefully acknowledge the Department of Biotechnology (DBT), Government of India for the financial support (Sanction Nos. BT/PR15018/MED/32/447/2015 and BT/PR4076/MED/32/221/2011).

Author information

Correspondence to T. G. Satheesh Babu.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 252 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sreekumar, A., Navaneeth, P., Suneesh, P.V. et al. A graphite pencil electrode with electrodeposited Pt-CuO for nonenzymatic amperometric sensing of glucose over a wide linear response range. Microchim Acta 187, 113 (2020) doi:10.1007/s00604-019-4077-2

Download citation

Keywords

  • Graphite pencil electrode
  • Pulsed electrodeposition
  • Chronopotentiometry
  • Pt-CuO nanomaterials
  • Bi-metalic catalyst
  • Direct electrochemical oxidation
  • Blood glucose