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A nickel–cobalt bimetallic phosphide nanocage as an efficient electrocatalyst for nonenzymatic sensing of glucose

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The authors describe Ni–Co bimetal phosphide (NiCoP) nanocages that exhibit enhanced electrocatalytic performance toward glucose oxidation. The nanocages offer an appealing architecture, large specific area, and good accessibility for the analyte glucose. When placed on a glassy carbon electrode, the sensor exhibits attractive figures of merit for sensing glucose in 0.1 M NaOH solution including (a) a wide linear range (0.005–7 mM), (b) a low determination limit (0.36 μM), (c) high sensitivity (6115 μA•μM−1•cm−2), (d) a relatively low working potential (0.50 V vs. Ag/AgCl), and (e) good selectivity, reproducibility, and stability. The sensor is successfully applied to the determination of glucose in human serum samples.

Schematic representation of a glassy carbon electrode modified with Ni–Co bimetal phosphide (NiCoP) nanocage. NiCoP nanocage exhibits excellent electrocatalytic activity toward glucose oxidation. NiCoP nanocage is applied in a sensitive non-enzymatic glucose sensor.

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The authors gratefully acknowledge the financial support from the Natural Science Foundation of Hebei Province (Grant No. B2019206437, H2017206214), Chunyu Project Outstanding Youth Fund of Hebei Medical University (No. CYYQ201903), the Undergraduate Innovation Project (No. USIP2019092), and the Education Department of Hebei Province of China for Funding Through the Innovative Hundred Talents Support Program (SLRC2017047).

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Correspondence to Yanyan Zhu or Jing Wang.

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The author(s) declare that they have no competing interests.

Ethics statement

The human serum was used in this manuscript with the informed consent of the donors. The experimental design and protocols used in this study were approved by the Regulation of the Hebei Medical University of Research Ethics Committee.

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Zhu, Y., Wang, Y., Kang, K. et al. A nickel–cobalt bimetallic phosphide nanocage as an efficient electrocatalyst for nonenzymatic sensing of glucose. Microchim Acta 187, 100 (2020). https://doi.org/10.1007/s00604-019-4073-6

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  • Electrochemical sensor
  • Electrocatalytic activity
  • Hollow nanostructure
  • High sensitivity
  • Cyclic voltammetry
  • Good selectivity
  • Amperometric
  • Electron transport
  • Electrocatalytic oxidation
  • Human serum