The authors describe Ni–Co bimetal phosphide (NiCoP) nanocages that exhibit enhanced electrocatalytic performance toward glucose oxidation. The nanocages offer an appealing architecture, large specific area, and good accessibility for the analyte glucose. When placed on a glassy carbon electrode, the sensor exhibits attractive figures of merit for sensing glucose in 0.1 M NaOH solution including (a) a wide linear range (0.005–7 mM), (b) a low determination limit (0.36 μM), (c) high sensitivity (6115 μA•μM−1•cm−2), (d) a relatively low working potential (0.50 V vs. Ag/AgCl), and (e) good selectivity, reproducibility, and stability. The sensor is successfully applied to the determination of glucose in human serum samples.
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Hwang D-W, Lee S, Seo M, Chung TD (2018) Recent advances in electrochemical non-enzymatic glucose sensors – a review. Anal Chim Acta 1033:1–34
Dhara K, Mahapatra DR (2017) Electrochemical nonenzymatic sensing of glucose using advanced nanomaterials. Microchim Acta 185(1):49
Xie L, Asiri AM, Sun X (2017) Monolithically integrated copper phosphide nanowire: an efficient electrocatalyst for sensitive and selective nonenzymatic glucose detection. Sensor Actuat B-Chem 244:11–16
Chen T, Liu D, Lu W, Wang K, Du G, Asiri AM, Sun X (2016) Three-dimensional Ni2P Nanoarray: an efficient catalyst electrode for sensitive and selective nonenzymatic glucose sensing with high specificity. Anal Chem 88(16):7885–7889
Vilian ATE, Dinesh B, Rethinasabapathy M, Hwang S-K, Jin C-S, Huh YS, Han Y-K (2018) Hexagonal Co3O4 anchored reduced graphene oxide sheets for high-performance supercapacitors and non-enzymatic glucose sensing. J Mater Chem A 6(29):14367–14379
Long L, Liu X, Chen L, Li D, Jia J (2019) A hollow CuOx/NiOy nanocomposite for amperometric and non-enzymatic sensing of glucose and hydrogen peroxide. Microchim Acta 186(2):74
Liu L, Wang Z, Yang J, Liu G, Li J, Guo L, Chen S, Guo Q (2018) NiCo2O4 nanoneedle-decorated electrospun carbon nanofiber nanohybrids for sensitive non-enzymatic glucose sensors. Sensor Actuat B-Chem 258:920–928
Li R, Liu X, Wang H, Wu Y, Chan KC, Lu Z (2019) Sandwich nanoporous framework decorated with vertical CuO nanowire arrays for electrochemical glucose sensing. Electrochim Acta 299:470–478
Huang Y, Tan Y, Feng C, Wang S, Wu H, Zhang G (2018) Synthesis of CuO/g-C3N4 composites, and their application to voltammetric sensing of glucose and dopamine. Microchim Acta 186(1):10
Foroughi F, Rahsepar M, Hadianfard MJ, Kim H (2017) Microwave-assisted synthesis of graphene modified CuO nanoparticles for voltammetric enzyme-free sensing of glucose at biological pH values. Microchim Acta 185(1):57
Li W, Qi H, Wang B, Wang Q, Wei S, Zhang X, Wang Y, Zhang L, Cui X (2018) Ultrathin NiCo2O4 nanowalls supported on a 3D nanoporous gold coated needle for non-enzymatic amperometric sensing of glucose. Microchim Acta 185(2):124
Wang R, Liang X, Liu H, Cui L, Zhang X, Liu C (2018) Non-enzymatic electrochemical glucose sensor based on monodispersed stone-like PtNi alloy nanoparticles. Microchim Acta 185(7):339
Lu L, Kang J (2018) Amperometric nonenzymatic sensing of glucose at very low working potential by using a nanoporous PdAuNi ternary alloy. Microchim Acta 185(2):111
Pal N, Banerjee S, Bhaumik A (2018) A facile route for the syntheses of Ni(OH)2 and NiO nanostructures as potential candidates for non-enzymatic glucose sensor. J Colloid Interface Sci 516:121–127
Wang F, Zhang Y, Liang W, Chen L, Li Y, He X (2018) Non-enzymatic glucose sensor with high sensitivity based on cu-Al layered double hydroxides. Sensor Actuat B-Chem 273:41–47
Meng A, Yuan X, Li Z, Zhao K, Sheng L, Li Q (2019) Direct growth of 3D porous (Ni-co)3S4 nanosheets arrays on rGO-PEDOT hybrid film for high performance non-enzymatic glucose sensing. Sensor Actuat B-Chem 291:9–16
Luo J, Zhao D, Yang M, Qu F (2018) Porous Ni3N nanosheet array as a catalyst for nonenzymatic amperometric determination of glucose. Microchim Acta 185(4):229
Liu Y, Cao X, Kong R, Du G, Asiri AM, Lu Q, Sun X (2017) Cobalt phosphide nanowire array as an effective electrocatalyst for non-enzymatic glucose sensing. J Mater Chem B 5(10):1901–1904
Zhang Y, Xu J, Xia J, Zhang F, Wang Z (2018) MOF-derived porous Ni2P/Graphene composites with enhanced electrochemical properties for sensitive nonenzymatic glucose sensing. ACS Appl Mater Interfaces 10(45):39151–39160
Das D, Das A, Reghunath M, Nanda KK (2017) Phosphine-free avenue to Co2P nanoparticle encapsulated N,P co-doped CNTs: a novel non-enzymatic glucose sensor and an efficient electrocatalyst for oxygen evolution reaction. Green Chem 19(5):1327–1335
Sedighi A, Montazer M, Mazinani S (2019) Synthesis of wearable and flexible NiP0.1-SnOx/PANI/CuO/cotton towards a non-enzymatic glucose sensor. Biosens Bioelectron 135:192–199
Wang Z, Cao X, Liu D, Hao S, Du G, Asiri AM, Sun X (2016) Ternary NiCoP nanosheet array on a Ti mesh: a high-performance electrochemical sensor for glucose detection. Chem Commun 52(100):14438–14441
Ma J, Chen Y, Chen L, Wang L (2017) Ternary Pd–Ni–P nanoparticle-based nonenzymatic glucose sensor with greatly enhanced sensitivity achieved through active-site engineering. Nano Res 10(8):2712–2720
Wang M, Ma Z, Li J, Zhang Z, Tang B, Wang X (2018) Well-dispersed palladium nanoparticles on nickel- phosphorus nanosheets as efficient three-dimensional platform for superior catalytic glucose electro-oxidation and non-enzymatic sensing. J Colloid Interface Sci 511:355–364
Amin BG, Masud J, Nath M (2019) A non-enzymatic glucose sensor based on a CoNi2Se4/rGO nanocomposite with ultrahigh sensitivity at low working potential. J Mater Chem A 7(14):2338–2348
Sun Q-Q, Wang M, Bao S-J, Wang YC, Gu S (2016) Analysis of cobalt phosphide (CoP) nanorods designed for non-enzyme glucose detection. Analyst 141(1):256–260
Qiu B, Cai L, Wang Y, Lin Z, Zuo Y, Wang M, Chai Y (2018) Fabrication of nickel–cobalt bimetal phosphide nanocages for enhanced oxygen evolution catalysis. Adv Funct Mater 28:1706008
He P, Yu X-Y, Lou XW (2017) Carbon-incorporated nickel–cobalt mixed metal phosphide Nanoboxes with enhanced Electrocatalytic activity for oxygen evolution. Angew Chem Int Ed 56(14):3897–3900
Tian J, Chen J, Liu J, Tian Q, Chen P (2018) Graphene quantum dot engineered nickel-cobalt phosphide as highly efficient bifunctional catalyst for overall water splitting. Nano Energy 48:284–291
Yang M, Jeong J-M, Lee KG, Kim DH, Lee SJ, Choi BG (2017) Hierarchical porous microspheres of the Co3O4@graphene with enhanced electrocatalytic performance for electrochemical biosensors. Biosens Bioelectron 89:612–619
Qazzazie D, Yurchenko O, Urban S, Kieninger J, Urban G (2017) Platinum nanowires anchored on graphene-supported platinum nanoparticles as a highly active electrocatalyst towards glucose oxidation for fuel cell applications. Nanoscale 9(19):6436–6447
Zhu Y, Zhang X, Sun J, Li M, Lin Y, Kang K, Meng Y, Feng Z, Wang J (2019) A non-enzymatic amperometric glucose sensor based on the use of graphene frameworks-promoted ultrafine platinum nanoparticles. Microchim Acta 186(8):538
Guan BY, Yu L, Lou XW (2017) Formation of single-holed cobalt/N-doped carbon hollow particles with enhanced Electrocatalytic activity toward oxygen reduction reaction in alkaline media. Adv Sci 4(10):1700247
Mazaheri M, Aashuri H, Simchi A (2017) Three-dimensional hybrid graphene/nickel electrodes on zinc oxide nanorod arrays as non-enzymatic glucose biosensors. Sensor Actuat B-Chem 251:462–471
Tian Q, Xu J, Zuo Y, Li Y, Zhang J, Zhou Y, Duan X, Lu L, Jia H, Xu Q, Yu Y (2019) Three-dimensional PEDOT composite based electrochemical sensor for sensitive detection of chlorophenol. J Electroanal Chem 837:1–9
The authors gratefully acknowledge the financial support from the Natural Science Foundation of Hebei Province (Grant No. B2019206437, H2017206214), Chunyu Project Outstanding Youth Fund of Hebei Medical University (No. CYYQ201903), the Undergraduate Innovation Project (No. USIP2019092), and the Education Department of Hebei Province of China for Funding Through the Innovative Hundred Talents Support Program (SLRC2017047).
The author(s) declare that they have no competing interests.
The human serum was used in this manuscript with the informed consent of the donors. The experimental design and protocols used in this study were approved by the Regulation of the Hebei Medical University of Research Ethics Committee.
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Zhu, Y., Wang, Y., Kang, K. et al. A nickel–cobalt bimetallic phosphide nanocage as an efficient electrocatalyst for nonenzymatic sensing of glucose. Microchim Acta 187, 100 (2020). https://doi.org/10.1007/s00604-019-4073-6
- Electrochemical sensor
- Electrocatalytic activity
- Hollow nanostructure
- High sensitivity
- Cyclic voltammetry
- Good selectivity
- Electron transport
- Electrocatalytic oxidation
- Human serum