Microchimica Acta

, 186:830 | Cite as

Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules

  • Yanfang Zhao
  • Hanyi Xie
  • Mei Zhao
  • Huijuan Li
  • Xiangfeng ChenEmail author
  • Zongwei Cai
  • Hexing Song
Original Paper


Mesoporous carbon hollow spheres coated with MoS2 (C@MoS2) were synthesized to obtain a material with large specific surface area, fast electron transfer efficiency and good water dispersibility. The composite material was applied as a matrix for the analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). The use of a core-shell C@MoS2 matrix strongly reduces matrix background interferences and increases signal intensity in the analysis of sulfonamides antibiotics (SAs), cationic dyes, emodin, as well as estrogen and amino acids. The composite material was applied to the SALDI-TOF MS analysis of selected molecules in (spiked) real samples. The ionization mechanism of the core-shell C@MoS2 as a matrix is discussed. The method exhibits low fragmentation interference, excellent ionization efficiency, high reproducibility and satisfactory salt tolerance.

Graphical abstract

Schematic representation of the method for fabrication of MoS2-coated mesoporous carbon hollow spheres (core-shell C@MoS2). As a new matrix, the nanocomposites were applied to analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry.


Core-shell C@MoS2 SALDI-TOF MS Ionization mechanism Salt tolerance Sulfonamides antibiotics Cationic dyes Emodin Estrogen Amino acids 



This work was supported by The National Key Research and Development Program of China (2018YFC1603500), Natural Science Foundation of Shandong Province (ZR2017MB011), Key R&D Program of Shandong Province (2019GSF111009, 2019GSF111001), Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS(NSKF201813), the Special Grant for High-Level Overseas Talents of Shandong Academy of Sciences, Youth Science Funds of Shandong Academy of Sciences (2019QN008,2019QN009).

Supplementary material

604_2019_3960_MOESM1_ESM.docx (1.6 mb)
ESM 1 (DOCX 1677 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test CentreQilu University of Technology (Shandong Academy of Sciences)JinanChina
  2. 2.State Key Laboratory of Environmental and Biological Analysis, Department of ChemistryHong Kong Baptist UniversityHong KongPeople’s Republic of China
  3. 3.Intelligene Biosystems (QingDao) Co. Ltd.QingdaoChina

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