Microchimica Acta

, 186:758 | Cite as

Copper(II) 1,4-naphthalenedicarboxylate on copper foam nanowire arrays for electrochemical immunosensing of the prostate specific antigen

  • Zi-Ang Chen
  • Wenbo LuEmail author
  • Cancan Bao
  • Qiangqiang Niu
  • Xiaowei Cao
  • Hui Wang
  • Ru-Xin YaoEmail author
Original Paper


Nanowires of copper(II)-based metal-organic frameworks (Cu-MOFs) of type Cu(II)(1,4-naphthalenedicarboxylic acid) (1,4-NDC) were deposited on the surface of a copper foam by immersion of Cu(OH)2 nanowires in a solution of 1,4-NDC. An electrochemical immunosensor for the prostate specific antigen (PSA) is obtained by using the nanowire arrays as a redox signal probe. The signal is generated by the conversion of Cu(I) and Cu(II) of Cu-MOFs nanowires. Cu(1,4-NDC) nanowires contain many uncoordinated carboxyl groups which can bind to the amino groups of the PSA antibody. When PSA antibody binds to PSA antigen during an immune response, the current signal will decrease due to the electrical insulation of PSA antigen. The decrease of current is directly proportional to the increase of PSA concentration. The immunosensor, best operated at a voltage of typically −0.08 V (vs. Ag/AgCl), has a low limit of detection (4.4 fg·mL−1) and a wide linear range (0.1 pg·mL−1 to 20 ng·mL−1). This meets the demands of clinical diagnosis (with values <4 ng·mL−1) in serum. The method was applied to the determination of PSA in spiked serum.

Graphical abstract

Schematic representation of the in-situ growth of ordered Cu-MOFs wrapped with Cu(OH)2 nanowires, building the core-shell structure as the 3D electrode. A novel electrochemical immunosensor for PSA detection has been exploited, using the Cu-MOFs nanowire arrays on Cu foam as a redox signal probe for the first time.


Metal organic frameworks Nanomaterial Square wave voltammetry Electrochemical immunosensor Core-shell structure 



This work was supported by the National Natural Science Foundation of China (No.21705103), the Applied Basic Research Project of Shanxi Province (No. 201801D221392), the Science and Technology Innovation Projects of Universities in Shanxi Province, the Graduate Education Innovation Project of Shanxi Province (2018SY057), Collaborative Innovation Center for Shanxi Advanced Permanent Materials and Technology, and the 1331 Engineering of Shanxi Province.

Compliance with ethical standards

Conflict of interest

There are no conflicts to declare.

Supplementary material

604_2019_3891_MOESM1_ESM.docx (2.6 mb)
ESM 1 (DOCX 2649 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Magnetic Molecules and Magnetic Information Materials (Ministry of Education), School of Chemistry and Material ScienceShanxi Normal UniversityLinfenChina
  2. 2.Institute of Translational Medicine, Medical CollegeYangzhou UniversityYangzhouChina

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