A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection
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A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.
KeywordsHydrothermal synthesis Non-steroidal anti-inflammatory drug Pharmaceuticals Urine samples Water samples Magnetic separation Hummers method Nanosorbent
This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.
Compliance with ethical standards
Conflicts of interest
The author(s) declare that they have no competing interests.
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