Microchimica Acta

, 186:740 | Cite as

Luminescent metal organic frameworks with recognition sites for detection of hypochlorite through energy transfer

  • Lan Guo
  • Yuan Liu
  • Fengli Qu
  • Zhe Liu
  • Rongmei Kong
  • Guang Chen
  • Wenjing Fan
  • Lian XiaEmail author
Original Paper


A luminescent metal organic framework (LMOF) of type UiO-66-NH2 was chosen for specific and sensitive detection of trace levels of hypochlorite. Hypochlorite causes the quenching of the blue fluorescence of nano-UiO-66-NH2 (with excitation/emission maxima at 325/430 nm), and this finding forms the basis for a fluorometric assay for hypochlorite. The method overcomes disadvantages of conventional redox-probes which are interfered by oxidants with oxidation capability stronger than that of hypochlorite. Compared with other fluorescent probes for sensing hypochlorite, UiO-66-NH2 has a comparable detection limit of 0.3 μmol L−1 and a broad linearity relationship in the range of 1–8 μmol L−1. The probe was successfully applied to the detection of hypochlorite in complex water samples and living Hela cells.

Graphical abstract

Schematic representation of hypochlorite induced quenching of the blue fluorescence of nano-UiO-66-NH2 (with excitation/emission maxima at 325/430 nm) through energy transfer. It overcomes disadvantages of conventional redox-probes which are interfered by oxidants with oxidation capability stronger than that of hypochlorite.


UiO-66-NH2 Zr-based MOFs Amino functionalized MOF Non-redox mechanism Fluorescence quenching Porous materials Water samples DPD method 



The authors thank Dr. Kathryn R. Williams for manuscript review. This work is supported by grants awarded by the National Institute of Health (GM079359 and CA133086) and the National Natural Science Foundation of China (No. 21505084, 21775089).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

604_2019_3806_MOESM1_ESM.docx (521 kb)
ESM 1 (DOCX 521 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Life-Organic Analysis of Shandong ProvinceQufu Normal UniversityQufuPeople’s Republic of China
  2. 2.Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleUSA

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