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Microchimica Acta

, 186:644 | Cite as

A nanocomposite prepared from silver nanoparticles and carbon dots with peroxidase mimicking activity for colorimetric and SERS-based determination of uric acid

  • Ailin Wang
  • Ce Guan
  • Guiye ShanEmail author
  • Yanwei Chen
  • Chunliang Wang
  • Yichun Liu
Original Paper
  • 222 Downloads

Abstract

Silver-carbon dots (Ag-CDs) nanocomposites with excellent peroxidase-like and surface-enhanced Raman scattering (SERS) activities were fabricated by reducing silver ion with carbon dots. The formation of the core-shell structure was demonstrated by transmission electron microscopy. The Ag-CD nanocomposite catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to form oxidized TMB (oxTMB) that has a blue color with an absorption maximum at 652 nm. The catalytic activity originates from the fact that the electrons of CDs are transferred to H2O2 and decompose H2O2 into hydroxy radicals. The nanocomposites can be used for uric acid (UA) detection because UA can reduce oxTMB to form colorless TMB. The absorbance drops as the concentration of UA increases from 1 to 500 μM. The SERS signal of oxTMB can be detected (at 1605 cm−1) using the Ag-CD nanocomposites as SERS substrate. The intensity of the SERS signal decreases when the concentration of UA ranges from 0.01 to 500 μM.

Graphical abstract

Schematic representation of the fabrication of silver-carbon dots (Ag-CDs). The Ag-CDs catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2 to form blue-colored oxidized TMB (oxTMB). UA reduces oxTMB to form colorless TMB. This process is monitored by surface-enhanced Raman scattering (SERS) spectra for UA detection.

Keywords

Artificial nanozyme Core-shell nanoparticles Optical electric field Catalysis Electron transfer Hydroxy radicals Hydrogen peroxide 3,3',5,5'-Tetramethylbenzidine 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (11774048, 11374046), and the Project from Key Laboratory for UV-Emitting Materials and Technology of Ministry of Education (No. 130028723).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3759_MOESM1_ESM.docx (1.9 mb)
ESM 1 (DOCX 1914 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Ailin Wang
    • 1
  • Ce Guan
    • 1
  • Guiye Shan
    • 1
    • 2
    Email author
  • Yanwei Chen
    • 1
  • Chunliang Wang
    • 1
  • Yichun Liu
    • 1
  1. 1.Centre for Advanced Optoelectronic Functional Materials Research, Key Laboratory for UV Light-Emitting Materials and Technology of the Ministry of EducationNortheast Normal UniversityChangchunPeople’s Republic of China
  2. 2.National Demonstration Center for Experimental Physics EducationNortheast Normal UniversityChangchunPeople’s Republic of China

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