Non-conjugated polymer carbon dots for fluorometric determination of metronidazole
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Non-conjugated polymer carbon dots (PCDs) with a 9% fluorescence quantum yield were synthesized by a pyrolytic method using polyethyleneimine as the sole precursor. The PCDs have an average size about 2.1 nm and a blue fluorescence, with excitation/emission maxima at 380/457 nm, that is quenched by the drug metronidazole. The method has a linear response in the 0.06–15 μg mL−1 metronidazole concentration range and a 20 ng mL−1 detection limit. Milk samples were spiked at two levels (0.6 and 5.0 μg mL−1), and the recoveries of metronidazole are in the range of 96.7–102.2%.
KeywordsFluorescent material Fluorescent probe Inner-filter effect Polyethyleneimine Antibiotics Milk Metronidazole
This work received the support of the Development Program of the Ministry of Science and Technology of Jilin Province, China (Grant number 20180201011GX).
The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. ‡These authors contributed equally.
Compliance with ethical standards
The author(s) declares that they have no competing interests.
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