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Microchimica Acta

, 186:615 | Cite as

A poly(glycidyl-co-ethylene dimethacrylate) nanohybrid modified with β-cyclodextrin as a sorbent for solid-phase extraction of phenolic compounds

  • Carolina Belenguer-Sapiña
  • Enric Pellicer-Castell
  • Carlos Vila
  • Ernesto Francisco Simó-Alfonso
  • Pedro Amorós
  • Adela R. Mauri-AucejoEmail author
Original Paper
  • 49 Downloads

Abstract

A hybrid material made of β-cyclodextrin anchored to a polymeric network is described and evaluated as a sorbent for solid-phase extraction of phenolic compounds (phenol, cresol isomers, 2-methoxy-4-vinylphenol, 4-ethylphenol, 4-vinylphenol, 4-ethylguaiacol, guaiacol, and eugenol). The polymeric backbone of the sorbent consists of a poly(glycidyl-co-ethylene dimethacrylate) network, whose surface has been modified with β-cyclodextrin by a click-chemistry based procedure. The resulting material has been characterized by different techniques, and it has shown to be viable as a sorbent for its use in extraction cartridges. In this way, a method for the determination of the above analytes in tea has been validated. Under optimum conditions, the method has good repeatability, with coefficients of variation between 0.6 and 7.2%. In addition, recoveries from spiked samples at the level of 50 μg L−1 are between 57 and 101%. The method has been then applied to the determination of phenolic compounds in the drinkable portion of infusions made from tea bags. The quantification has been carried out by using gas chromatography coupled to a mass spectrometry detector. Following their elution from the sorbent with a mixture of acetonitrile and methanol, the limits of quantification reached are between 4.6 and 400 μg L−1. Results have been compared with those obtained with a reference method by using the paired t-test for comparing individual differences. The solid phase is reusable, and no cyclodextrin is lost during extraction due to its covalent anchoring to the polymeric support.

Graphical abstract

Schematic representation of the structure and characterization of the hybrid material made of β-cyclodextrin anchored to a polymeric network. The material is described and evaluated as a sorbent for the solid-phase extraction of phenolic compounds.

Keywords

Surface modification Polymeric material Host-guest chemistry Covalent anchoring Tea analysis Sample treatment 

Notes

Acknowledgments

This work has been supported by project PROMETEO/2016/145 (Generalitat Valenciana) and projects MAT2015-64139-C4-R and RTI2018-100910-B-C44 (Ministerio de Economía y Competitividad of Spain and FEDER). C. B-S thanks the University of Valencia for a Ph.D. grant VLC-CAMPUS “Atracció de Talent” and E. P-C thanks the Ministerio de Educación y Formación Profesional of Spain for an FPU grant for his Ph.D. studies. Authors also thank Professor José Ramón Pedro (Department of Organic Chemistry, University of Valencia) for his help.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3739_MOESM1_ESM.docx (2.8 mb)
ESM 1 (DOCX 2854 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Carolina Belenguer-Sapiña
    • 1
  • Enric Pellicer-Castell
    • 1
  • Carlos Vila
    • 2
  • Ernesto Francisco Simó-Alfonso
    • 1
  • Pedro Amorós
    • 3
  • Adela R. Mauri-Aucejo
    • 1
    Email author
  1. 1.Department of Analytical Chemistry, Faculty of ChemistryUniversity of ValenciaBurjassotSpain
  2. 2.Department of Organic Chemistry, Faculty of ChemistryUniversity of ValenciaBurjassotSpain
  3. 3.Institute of Material Science (ICMUV)University of ValenciaPaternaSpain

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