Microchimica Acta

, 186:532 | Cite as

Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres

  • Dalibor M. StankovićEmail author
  • Milica Jović
  • Miloš Ognjanović
  • Andreas Lesch
  • Martin Fabián
  • Hubert H. Girault
  • Bratislav Antić
Original Paper


An electrochemical sensor is described for the determination of L-dopa (levodopa; 3,4-dihydroxyphenylalanine). An inkjet-printed carbon nanotube (IJPCNT) electrode was modified with manganese dioxide microspheres by drop-casting. They coating was characterized by field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and X-ray powder diffraction. The sensor, best operated at a working voltage of 0.3 V, has a linear response in the 0.1 to 10 μM L-dopa concentration range, a 54 nM detection limit, excellent reproducibility, repeatability and selectivity. The amperometric approach was applied to the determination of L-dopa in spiked biological fluids and displayed satisfactory accuracy and precision.

Graphical abstract

Schematic representation of an amperometric method for determination L-dopa. It is based on the use of inkjet-printed carbon nanotube electrode (IJPCNT) modified with manganese dioxide (MnO2).


Levodopa Electrochemical sensor Manganese dioxide Cyclic voltammetry Amperometry Point-of-care 



This work was supported by MagBioVin project (FP7-ERAChairs-Pilot Call-2013, Grant agreement: 621375), by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project No. OI 172030, Project OI172049).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3644_MOESM1_ESM.docx (985 kb)
ESM 1 (DOCX 984 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.The “Vinča” Institute of Nuclear SciencesUniversity of BelgradeBelgradeSerbia
  2. 2.Laboratory of Physical and Analytical Electrochemistry (LEPA)EPFL Valais WallisSionSwitzerland
  3. 3.Department of Industrial Chemistry “Toso Montanari”University of BolognaBolognaItaly
  4. 4.Institute of Geotechnics SASKošiceSlovak Republic

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