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Microchimica Acta

, 186:279 | Cite as

Mesoporous graphitic carbon nitride as an efficient sorbent for extraction of sulfonamides prior to HPLC analysis

  • Jing Zhang
  • Wenqi Li
  • Wenli Zhu
  • Yixin Yang
  • Peige Qin
  • Qian Zhou
  • Minghua LuEmail author
  • Zongwei CaiEmail author
Original Paper
  • 71 Downloads

Abstract

Mesoporous graphitic carbon nitride (MCN) is shown to be a viable sorbent for the enrichment of sulfonamides (SAs). To overcome the difficulty of separating the sorbent from the matrix, a novel type kind of column-assisted dispersive solid-phase extraction (CA-dSPE) method was designed. The MCN was characterized by scanning electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, fourier transform infrared spectroscopy and nitrogen adsorption-desorption measurements. The amount of sorbent, the pH value of the sample, the adsorption time, type and volume of the eluent and desorption time were optimized. The SAs were eluted from the sorbent with elution solvent of methanol containing 10% (v/v) ammonia and then submitted to HPLC analysis. Under the optimized conditions, the limits of detection for the SAs investigated (sulfadiazine, sulfameter, sulfachloropyridazine, sulfabenzamide and sulfadimethoxine) range from 20 to 5 pg·mL−1. Satisfactory recoveries were obtained for spiked environmental water (90.1–110.5%) and milk samples (82.3–102.7%), with relative standard deviations of 0.5–3.8% and 1.1–4.4%, respectively. The method is simple, time saving and sensitive.

Graphical abstract

Schematic presentation of a column assisted dispersive solid-phase extraction by using mesoporous graphitic carbon nitride as sorbent combined with high performance liquid chromatography for sensitive analysis of sulfonamides in environmental water and milk samples.

Keywords

Column assisted dispersive solid-phase extraction Sample pretreatment Mesoporous material Antibiotic analysis High performance liquid chromatography DAD detector Ultratrace analysis Sensitive detection Environmental water Milk sample 

Notes

Acknowledgements

This work was supported by the National Nature Science Foundation of China (21477033), Program for Science & Technology Innovation Talents in Universities of Henan Province (17HASTIT003), and the Program for Development in Science and Technology of Henan Province (172102310608).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3394_MOESM1_ESM.doc (567 kb)
ESM 1 (DOC 567 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Environmental and Analysis Science, Center for Multi-Omic Research, School of Chemistry and Chemical EngineeringHenan UniversityKaifengChina
  2. 2.State Key Laboratory of Environmental and Biological Analysis, Department of ChemistryHong Kong Baptist UniversityHong KongChina

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