Non-enzymatic fluorescent glucose sensor using vertically aligned ZnO nanotubes grown by a one-step, seedless hydrothermal method
- 90 Downloads
A sensitive non-enzymatic fluorescent glucose sensor, consisting of vertically aligned ZnO nanotubes (NTs) grown on low-cost printed circuit board substrates, is described. The ZnO NTs were synthesized by a one-step hydrothermal method without using a seed layer. The sensor function is based on the photoluminescence (PL) quenching of ZnO NTs treated with different concentrations of glucose. The UV emission (emission maximum at 384 nm under 325 nm excitation) decreases linearly with increasing glucose concentration. The sensor exhibits a sensitivity of 3.5%·mM−1 (defined as percentage change of the PL peak intensity per mM) and a lower limit of detection (LOD) of 70 μM. This is better than previously reported work based on the use of ZnO nanostructures. The detection range is 0.1–15 mM which makes the sensor suitable for practical uses in glucose sensing. The sensor was successfully applied to the analysis of human blood serum samples. It is not interfered by common concentrations of ascorbic acid, uric acid, bovine serum albumin, maltose, fructose, and sucrose.
KeywordsZnO nanostructures Non-enzymatic sensor Fluorometric sensor Glucose sensing Printed circuit board Hydrothermal synthesis Photoluminescence quenching
This work was supported by the National Foundation for Science and Technology Development (NAFOSTED) of Vietnam through Grant No. 103.03-2015.27.
Compliance with ethical standards
The author(s) declare that they have no competing interests.
- 4.Ahmad R, Tripathy N, Ahn M-S, Bhat KS, Mahmoudi T, Wang Y, Yoo JY, Kwon DW, Yang HY, Hahn YB (2017) Highly efficient non-enzymatic glucose sensor based on CuO modified vertically-grown ZnO Nanorods on electrode. Sci Rep 7:5715. https://doi.org/10.1038/s41598-017-06064-8 CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Sodzel D, Khranovskyy V, Beni V, Turner APF, Viter R, Eriksson MO, Holtz PO, Janot JM, Bechelany M, Balme S, Smyntyna V, Kolesneva E, Dubovskaya L, Volotovski I, Ubelis A, Yakimova R (2015) Continuous sensing of hydrogen peroxide and glucose via quenching of the UV and visible luminescence of ZnO nanoparticles. Microchim Acta 182:1819–1826. https://doi.org/10.1007/s00604-015-1493-9 CrossRefGoogle Scholar
- 10.Zhang R, Yin P-G, Wang N, Guo L (2009) Photoluminescence and Raman scattering of ZnO nanorods. Solid State Sci 11:865–869. https://doi.org/10.1016/j.solidstatesciences.2008.10.016 CrossRefGoogle Scholar
- 13.Scarpellini D, Paoloni S, Medaglia PG, Pizzoferrato R, Orsini A, Falconi C (2015) Structural and optical properties of dense vertically aligned ZnO nanorods grown onto silver and gold thin films by galvanic effect with iron contamination. Mater Res Bull 65:231–237. https://doi.org/10.1016/j.materresbull.2015.01.059 CrossRefGoogle Scholar
- 16.Bustos-Torres KA, Vazquez-Rodriguez S, la Cruz AM, Sepulveda-Guzman S, Benavides R, Lopez-Gonzalez R, Torres-Martínez LM (2017) Influence of the morphology of ZnO nanomaterials on photooxidation of polypropylene/ZnO composites. Mater Sci Semicond Process 68:217–225. https://doi.org/10.1016/j.mssp.2017.06.023 CrossRefGoogle Scholar
- 25.Ding Y, Chen M, Wu K, Chen M, Sun L, Liu Z, Shi Z, Liu Q (2017) High-performance peroxidase mimics for rapid colorimetric detection of H2O2 and glucose derived from perylene diimides functionalized Co3O4 nanoparticles. Mater Sci Eng C 80:558–565. https://doi.org/10.1016/j.msec.2017.06.020 CrossRefGoogle Scholar
- 27.Faccio G, Bannwarth MB, Schulenburg C, Steffen V, Jankowska D, Pohl M, Rossi RM, Maniura-Weber K, Boesel LF, Richter M (2016) Encapsulation of FRET-based glucose and maltose biosensors to develop functionalized silica nanoparticles. Analyst 141:3982–3984. https://doi.org/10.1039/C5AN02573G CrossRefPubMedGoogle Scholar
- 29.Hu Y, Cheng H, Zhao X, Wu J, Muhammad F, Lin S, He J, Zhou L, Zhang C, Deng Y, Wang P, Zhou Z, Nie S, Wei H (2017) Surface-enhanced Raman scattering active gold nanoparticles with enzyme-mimicking activities for measuring glucose and lactate in living tissues. ACS Nano 11:5558–5566. https://doi.org/10.1021/acsnano.7b00905 CrossRefPubMedGoogle Scholar
- 32.Bourdon E, Loreau NBD (1999) Glucose and free radicals impair the antioxidant properties of serum albumin. PubMed 13:233–244Google Scholar
- 34.Bruen D, Delaney C, Florea L, Diamond D (2017) Glucose sensing for diabetes monitoring: recent developments. Sensors 17. https://doi.org/10.3390/s17081866