Low fouling electrochemical sensing in complex biological media by using the ionic liquid-doped conducting polymer PEDOT: application to voltammetric determination of dopamine
- 59 Downloads
An electrochemical sensor that can resist biofouling even when operated in complex biological medium is developed for the determination of dopamine. It is based on the use of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) that is doped with the water insoluble ionic liquid (IL), 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. A glassy carbon electrode modified with PEDOT/IL is shown to enable accurate determination of dopamine, as a model analyte in the presence of high concentrations of proteins, and resist biological fouling even in native serum. It exhibited a low limit of detection of 33 nM for the detection of dopamine, with a wide linear range from 0.2 to 328 μM (at 0.2 V vs. saturated calomel electrode). The PEDOT/IL modified glassy carbon electrode has a porous microstructure, high electrical conductivity and good stability. The sensor can be used to quantify dopamine in human urine samples with satisfying accuracy.
KeywordsConducting polymer nanocomposite Electrochemical sensors Antifouling Poly(3,4-ethylenedioxythiophene) Electrodeposition Dopamine determination
This work is supported by the National Natural Science Foundation of China (21675093, 21422504), the Natural Science Foundation of Shandong Province of China (JQ201406), and the Taishan Scholar Program of Shandong Province of China (ts20110829).
Compliance with ethical standards
The author(s) declare that they have no competing interests.
- 5.Zhang ZG, Zheng JP, Zhang Y, Zhang W, Li LJ, Cao ZZ, Wang H, Li CH, Gao YF, Liu JR (2013) Anti-fouling in situ deposited antimony/nafion film electrode for electrochemical stripping analysis. Int J Electrochem Sci 8:4183–4193Google Scholar
- 21.Crispin X, Jakobsson FLE, Crispin A, Grim PCM, Andersson P, Volodin A, Haesendonck CV, Auweraer MVD, Salaneck WR, Berggren M (2006) The origin of the high conductivity of poly (3, 4-ethylenedioxythiophene)− poly (styrenesulfonate)(PEDOT− PSS) plastic electrodes. Chem Mater 18:4354–4360CrossRefGoogle Scholar
- 25.Liu S, Ma YH, Zhang RQ, Luo XL (2016) Three-dimensional Nanoporous conducting polymer poly (3, 4-ethylenedioxythiophene)(PEDOT) decorated with copper nanoparticles: electrochemical preparation and enhanced nonenzymatic glucose sensing. Chem Electro Chem 3:1799–1804Google Scholar
- 46.Khan MZH, Liu XQ, Tang YF, Zhu JH, Hu WP, Liu XH (2018) A glassy carbon electrode modified with a composite consisting of gold nanoparticle, reduced graphene oxide and poly (L-arginine) for simultaneous voltammetric determination of dopamine, serotonin and L-tryptophan. Microchim Acta 185(9):439CrossRefGoogle Scholar
- 49.Mei LP, Feng JJ, Wu L, Chen JR, Shen L, Xie Y, Wang AJ (2016) A glassy carbon electrode modified with porous Cu2O nanospheres on reduced graphene oxide support for simultaneous sensing of uric acid and dopamine with high selectivity over ascorbic acid. Microchim Acta 183:2039–2046CrossRefGoogle Scholar