Microchimica Acta

, 186:143 | Cite as

A molecularly imprinted polymer with integrated gold nanoparticles for surface enhanced Raman scattering based detection of the triazine herbicides, prometryn and simetryn

  • Mengmeng Yan
  • Yongxin SheEmail author
  • Xiaolin Cao
  • Jun Ma
  • Ge Chen
  • Sihui Hong
  • Yong Shao
  • A. M. Abd EI-Aty
  • Miao Wang
  • Jing WangEmail author
Original Paper


A class-specific molecular imprinted polymer (MIP) is described for simultaneous recognition of prometryn and simetryn prior to their determination via a fingerprint signal (at 974 cm−1 and 1074 cm−1) in the surface enhanced Raman scattering (SERS) spectra that were acquired in the presence of gold nanoparticles. The imprinted nanoparticles were applied to the analysis of rice and wheat samples spiked with both herbicides. The method has fairly good recoveries (72.7–90.9%) with a relative standard deviation of 1.7–7.8%, and a 20 μg·kg−1 limit of detection. The imprint factors (compared to non-imprinted polymers) are 5.3 for prometryn and 4.2 for simetryn (both at 10 μg·mL−1 of the initial solution).

Graphical abstract

A MIP-SERS method was developed for simultaneous detection of triazine herbicides (prometryn and simetryn) in food samples.


Simultaneous detection Herbicides Molecular imprint Food safety AuNPs Portable Raman spectrometer Matrix interference Multi-residues Grain 



The authors are grateful to the National Natural Science Foundation of China (contact No. 31471654, 31772071, and 31501571) and the China Agriculture Research System (NO. CARS-05-05A-03).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3254_MOESM1_ESM.docx (1.5 mb)
ESM 1 (DOCX 1.48 mb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Mengmeng Yan
    • 1
    • 2
  • Yongxin She
    • 1
    • 2
    Email author
  • Xiaolin Cao
    • 1
    • 2
  • Jun Ma
    • 1
    • 2
  • Ge Chen
    • 1
    • 2
  • Sihui Hong
    • 1
    • 2
  • Yong Shao
    • 1
    • 2
  • A. M. Abd EI-Aty
    • 3
    • 4
  • Miao Wang
    • 1
    • 2
  • Jing Wang
    • 1
    • 2
    Email author
  1. 1.Institute of Quality Standards & Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijingPeople’s Republic of China
  2. 2.Key Laboratory of Agro-product Safety and QualityMinistry of AgricultureBeijingPeople’s Republic of China
  3. 3.Department of Pharmacology, Faculty of Veterinary MedicineCairo UniversityGizaEgypt
  4. 4.Department of Medical Pharmacology, Medical FacultyAtaturk UniversityErzurumTurkey

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