Microchimica Acta

, 186:17 | Cite as

Gold nanorods decorated with graphene oxide and multi-walled carbon nanotubes for trace level voltammetric determination of ascorbic acid

  • Yiwei Zhao
  • Jianhua Qin
  • Hui Xu
  • Shanmin Gao
  • Tingting Jiang
  • Shengxiao Zhang
  • Juan Jin
Original Paper


An ultra-sensitive sensor is described for the voltammetric determination of ascorbic acid (AA). A glassy carbon electrode (GCE) was modified with graphene oxide (GO), multi-walled carbon nanotubes (MWCNTs) and gold nanorods (AuNRs). GO was used to prevent the aggregation of MWCNTs. The integration of positively charged AuNRs reduces the overpotential and increases the peak current of AA oxidation. Figures of merit of this sensor, typically operated at a low working potential of 0.036 V (vs. Ag/AgCl), include a low detection limit (0.85 nM), high sensitivity (7.61 μA·μM−1·cm−2) and two wide linear ranges (from 1 nM to 0.5 μM and from 1 μM to 8 mM). The use of GO simplifies the manufacture and results in a highly reproducible and stable sensor. It was applied to the quantification of AA in spiked serum.

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Graphene oxide (GO) in combination with multiwalled carbon nanotubes (MWCNTs) and gold nanorods (AuNRs) were used to construct a sensing interface with outstanding electrocatalytic performance for ascorbic acid detection.


Electrochemical sensor Modified electrode Hybrid material Electrocatalysis Differential pulse voltammetry 



This work was supported by the Natural Science Foundation of Shandong Province, China (Nos. ZR2016BM27 and ZR2017PB006).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3138_MOESM1_ESM.doc (360 kb)
ESM 1 (DOC 360 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Yiwei Zhao
    • 1
  • Jianhua Qin
    • 1
  • Hui Xu
    • 1
  • Shanmin Gao
    • 1
  • Tingting Jiang
    • 2
  • Shengxiao Zhang
    • 1
  • Juan Jin
    • 1
  1. 1.School of Chemistry and Materials ScienceLudong UniversityYantaiPeople’s Republic of China
  2. 2.College of Life SciencesLudong UniversityYantaiPeople’s Republic of China

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