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Microchimica Acta

, 185:370 | Cite as

A magnetic adsorbent grafted with pendant naphthyl polymer brush for enrichment of the nonsteroidal anti-inflammatory drugs indomethacin and diclofenac

  • Ya’nan Deng
  • Jiwei Shen
  • Jiawei Liu
  • Yinmao Wei
  • Chaozhan Wang
Original Paper
  • 40 Downloads

Abstract

Poly(2-naphthyl acrylate) was first grafted onto silica-coated magnetic nanoparticles by surface-initiated atom transfer radical polymerization to prepare a reversed-phase magnetic adsorbent. The resulting polymer brush displays enhanced extraction efficiency by offering active sites on the surfaces of adsorbent. It was applied to the preconcentration of the non-steroidal antiinflammatory drugs (NSAIDs) indomethacin (InDo) and diclofenac (DIC). These drugs interact with the sorbent through hydrophobic and π-interactions, and via electrostatic attraction. By coupling the magnetic solid-phase extraction with HPLC, a method for analysis of InDo and DIC in the environmental water samples was established. The limits of detection range from 0.62 to 0.64 ng·mL−1, and the relative standard deviations for intra-and inter-day analyses of spiked water samples are <11.9%, and relative recoveries are between 62.1 and 96.7%.

Graphical abstract

A reversed-phase magnetic adsorbent was prepared by grafting poly(2-naphthyl acrylate) brush on the surface of silica coated magnetic nanoparticles. Due to the two conjugated aromatic rings of the monomer, the polymer brush can effectively extract non-steroidal anti-inflammatory drugs through strong π- and hydrophobic interactions.

Keywords

Atom transfer radical polymerization Silica coating Surface modification Magnetic solid phase extraction π- interaction Hydrophobic interaction Adsorption Enrichment NSAIDs Reversed-phase adsorbents 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation in China (Nos. 21575114 and 21775121).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_2913_MOESM1_ESM.docx (998 kb)
ESM 1 (DOCX 997 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Key Laboratory, College of Chemistry and Materials ScienceNorthwest UniversityXi’anPeople’s Republic of China

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