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Microchimica Acta

, 185:368 | Cite as

Synthesis of tellurium nanosheet for use in matrix assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules

  • Ya-Shun Chen
  • Jun Ding
  • Xiao-Mei He
  • Jing Xu
  • Yu-Qi Feng
Original Paper
  • 153 Downloads

Abstract

Two-dimensional tellurium nanosheets were prepared by a hydrothermal method and characterized by scanning electron microscopy, powder X-ray diffractometry, and UV-vis spectroscopy. The nanosheets were explored as a novel matrix for desorption/ionization of small molecules including nucleobases, fatty acids and amino acids by matrix assisted laser desorption/ionization time-of-flight mass spectrometry. The results show that the tellurium nanosheets have good UV light absorption, cause low matrix ion interference in the low-molecule-mass region, and have high desorption/ionization efficiency in the negative ion mode. Hence, they are a viable matrix for negative ion desorption/ionization in MALDI-TOF MS of small molecules. In order to investigate the desorption/ionization mechanisms, benzylpyridinium salt and bisphenol A were adopted as probes. The results show that both of the electronic transitions mechanism and laser-induced thermal mechanism play important roles in desorption/ionization process.

Graphical abstract

Two-dimensional tellurium (Te) nanosheet was synthesized by a hydrothermal method and explored as a novel matrix for desorption/ionization of small molecules by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

Keywords

Tellurium nanorod Hydrothermal method MALDI-TOF MS Negative ion mode Electronic transitions mechanism Laser-induced thermal mechanism 

Notes

Acknowledgments

This work was funded by the National Key R&D Program of China (2017YFC0906800), National Natural Science Foundation of China (21635006, 21475098, 31670373, 21605117).

Compliance with ethical standards

The authors declare that they have no competing interests.

Supplementary material

604_2018_2882_MOESM1_ESM.docx (1.4 mb)
ESM 1 (DOCX 1385 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education)Wuhan UniversityWuhanPeople’s Republic of China

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