Microchimica Acta

, 185:125 | Cite as

An amino-functionalized magnetic framework composite of type Fe3O4-NH2@MIL-101(Cr) for extraction of pyrethroids coupled with GC-ECD

  • Xi He
  • Wei Yang
  • Sijia Li
  • Yu Liu
  • Baichun Hu
  • Ting WangEmail author
  • Xiaohong HouEmail author
Original Paper


An amino-functionalized magnetic framework composite of type Fe3O4-NH2@MIL-101(Cr) was synthesized using a solvothermal method. The material was characterized by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, nitrogen adsorption, and magnetometry. The composite combines the advantages of amino-modified Fe3O4 and MIL-101(Cr). The presence of amino groups facilitates the fairly specific adsorption of pyrethroids. The composite was employed as a sorbent for magnetic solid phase extraction of five pyrethroids from environmental water samples. Following desorption with acidified acetone, the pyrethroids were quantified by gas chromatography with electron capture detection. The detection limits for bifenthrin, fenpropathrin, λ-cyhalothrin, permethrin, and deltamethrin range from 5 to 9 pg·mL−1. The method is rapid, accurate, and highly sensitive. The molecular interactions and free binding energies between MIL-101(Cr) and the five pyrethroids were calculated by means of molecular docking.

Graphical abstract

A novel functionalized magnetic framework composite of type Fe3O4-NH2@MIL-101(Cr) was synthesized. It was applied as a sorbent for magnetic solid phase extraction of pyrethroids prior to their quantitation by gas chromatography with electron capture detection. The molecular interactions of analytes and MIL-101(Cr) were studied.


Sorbent Insecticides Magnetic solid phase extraction Environmental water samples Molecular docking 



This work was financially supported by the Natural Science Foundation of Liaoning Province, China (201602693), Natural Science Foundation of Liaoning Provincial Department of Education, China (2017LQN12).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_2672_MOESM1_ESM.docx (4.3 mb)
ESM 1 (DOCX 4376 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of PharmacyShenyang Pharmaceutical UniversityShenyangPeople’s Republic of China
  2. 2.School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyangPeople’s Republic of China

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