Microchimica Acta

, 185:127 | Cite as

Carbon nanotube-modified monolithic polymethacrylate pipette tips for (micro)solid-phase extraction of antidepressants from urine samples

  • Beatriz Fresco-Cala
  • Óscar Mompó-Roselló
  • Ernesto F. Simó-Alfonso
  • Soledad CárdenasEmail author
  • José Manuel Herrero-MartínezEmail author
Original Paper


This work evaluates the potential of methacrylate monoliths with multi-walled carbon nanotubes incorporated into the polymeric network for the extraction of antidepressants from human urine. The method is based on a micropipette solid-phase extraction tip containing a hybrid monolithic material covalently attached to the polypropylene housing. A polymer layer made from poly(ethylene dimethacrylate) was bound to the inner surface of a polypropylene tip via UV grafting. The preparation of the monolith and the microextraction steps were optimized in terms of adsorption capacity. Limits of detection ranged from 9 to 15 μg·L−1. The average precision of the method varied between 3 and 5% (intra-tips), and from 4 to 14% (inter-tips). The accuracy of the method was evaluated through a recovery study by using spiked samples.

Graphical abstract

Hybrid polymer monoliths containing multi-walled carbon nanotubes (MWCNTs) were prepared in pipette tips by photo-polymerization approach. The extraction devices were used for the extraction of antidepressants in urine samples.


Carbon nanoparticles Hybrid monolith Microextraction Porous polymer Photografting process UV attachment Drugs Liquid chromatography Biological samples 



Financial support from the Spanish Ministry of Science and Innovation (CTQ2014-52939-R and CTQ2014-52765-R) and PROMETEO/2016/145 (Conselleria de Educación, Investigación, Cultura y Deporte, Generalitat Valenciana, Spain) is gratefully acknowledged. B. Fresco-Cala expresses her gratitude for the predoctoral grant (ref FPU13/03896) from the Spanish Ministry of Education.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2659_MOESM1_ESM.doc (1.2 mb)
ESM 1 (DOC 1208 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Beatriz Fresco-Cala
    • 1
    • 2
  • Óscar Mompó-Roselló
    • 2
  • Ernesto F. Simó-Alfonso
    • 2
  • Soledad Cárdenas
    • 1
    Email author
  • José Manuel Herrero-Martínez
    • 2
    Email author
  1. 1.Departamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUNANUniversidad de CórdobaCórdobaSpain
  2. 2.Department of Analytical ChemistryUniversity of ValenciaBurjassotSpain

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