Voltammetric lidocaine sensor by using a glassy carbon electrode modified with porous carbon prepared from a MOF, and with a molecularly imprinted polymer
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The work describes a hybrid electrochemical sensor for highly sensitive detection of the anesthetic lidocaine (LID). Porous carbon (PC) was synthesized from an isoreticular metal-organic framework-8 (IRMOF-8) and drop cast onto a glassy carbon electrode (GCE). A layer of a molecularly imprinted polymer (MIP) layer was then fabricated in situ on the modified GCE by electro-polymerization, with LID acting as the template and resorcinol as the functional monomer. Hexacyanoferrate is used as an electrochemical probe. The electrical signal (typically acquired at 0.335 V vs. SCE) increases linearly in the 0.2 pM to 8 nM LID concentration range, with a remarkable 67 fM detection limit (at an S/N ratio of 3). The sensor is stable and selective. Eventually, rapid and accurate detection of LID in spiked real samples was successfully realized.
KeywordsMOF derived carbon Electrochemical sensor Cyclic voltammetry Trace measurement Scanning electron microscopy X-ray photoelectron spectroscopy Raman spectra Brunauer-Emmett-Teller Nanoporous material Hexacyanoferrate
The project financially supported by National Natural Science Foundation of China (81460543, 81773680, 61671308).
Compliance with ethical standards
The author(s) declare that they have no competing interests.
Conflict of Interest
We abide by compliance with ethical standards during the animal experiment.
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