Microchimica Acta

, 185:78 | Cite as

Voltammetric lidocaine sensor by using a glassy carbon electrode modified with porous carbon prepared from a MOF, and with a molecularly imprinted polymer

  • Junjie Zhang
  • Jiang Liu
  • Yang Zhang
  • Feng Yu
  • Fu Wang
  • Zhengchun PengEmail author
  • Yingchun LiEmail author
Original Paper


The work describes a hybrid electrochemical sensor for highly sensitive detection of the anesthetic lidocaine (LID). Porous carbon (PC) was synthesized from an isoreticular metal-organic framework-8 (IRMOF-8) and drop cast onto a glassy carbon electrode (GCE). A layer of a molecularly imprinted polymer (MIP) layer was then fabricated in situ on the modified GCE by electro-polymerization, with LID acting as the template and resorcinol as the functional monomer. Hexacyanoferrate is used as an electrochemical probe. The electrical signal (typically acquired at 0.335 V vs. SCE) increases linearly in the 0.2 pM to 8 nM LID concentration range, with a remarkable 67 fM detection limit (at an S/N ratio of 3). The sensor is stable and selective. Eventually, rapid and accurate detection of LID in spiked real samples was successfully realized.

Graphical abstract


MOF derived carbon Electrochemical sensor Cyclic voltammetry Trace measurement Scanning electron microscopy X-ray photoelectron spectroscopy Raman spectra Brunauer-Emmett-Teller Nanoporous material Hexacyanoferrate 



The project financially supported by National Natural Science Foundation of China (81460543, 81773680, 61671308).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Conflict of Interest

We abide by compliance with ethical standards during the animal experiment.

Supplementary material

604_2017_2551_MOESM1_ESM.docx (461 kb)
ESM 1 (DOCX 460 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of EducationShihezi UniversityShiheziChina
  2. 2.College of ScienceHarbin Institute of TechnologyShenzhenChina
  3. 3.Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical EngineeringShihezi UniversityShiheziChina
  4. 4.Laboratory of Environmental Science and Technology, The Xinjiang Technical Institute of Physics and Chemistry; Key Laboratory of Functional Materials and Devices for Special EnvironmentsChinese Academy of SciencesUrumqiChina
  5. 5.College of Optoelectronic EngineeringShenzhen UniversityShenzhenChina

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