Specific recognition and fluorescent determination of aspirin by using core-shell CdTe quantum dot-imprinted polymers
- 835 Downloads
A molecularly imprinted polymer (MIP) was deposited on the surface of CdTe quantum dots (QDs) to act as a recognition element for aspirin. The MIP was synthesized from 3-aminopropyltriethoxysilane as the functional monomer, aspirin as the template, and tetraethoxysilane as the cross-linker via a sol–gel process that leads to surface imprinting. It is shown that the fraction of QDs and the polymerization process affect size and morphology of the MIP-coated QDs. The optical stability, effects of pH, detection time and selective determination of aspirin were optimized. The fluorescence intensity of the particles (photoexcited at 400 nm and measured at 628 nm) decreases linearly with increasing concentration of aspirin in the 2.0–50 μmol L−1 range. The limit of detection (at an S/N of 3) is 0.25 μmol L−1. The method was successfully applied to the determination of aspirin in human urine and saliva.
KeywordsCdTe Polymer Selective Recognition Aspirin
This work was financially supported by the National Natural Science Foundation of China (No. 21107037, No. 21176107, No. 21174057, No. 21277063, No. 21407057 and No. 21407064), National Basic Research Program of China (973 Program, 2012CB821500), Natural Science Foundation of Jiangsu Province (No. BK20140535), Ph.D. Innovation Programs Foundation of Jiangsu Province (No. KYLX_1032), National Postdoctoral Science Foundation (No. 2014 M561595), Postdoctoral Science Foundation funded Project of Jiangsu Province (No. 1401108C).
- 4.Long CY, Mai ZB, Yang YF, Zhu BH, Xu XM, Lu L, Zou XY (2009) Determination of multi-residue for malachite green, gentian violet and their metabolites in aquatic products by high-performance liquid chromatography coupled with molecularly imprinted solid-phase extraction. J Chromatogr A 1216:2275–2281CrossRefGoogle Scholar