Microchimica Acta

, Volume 181, Issue 7–8, pp 689–705 | Cite as

Advances in enzyme-free electrochemical sensors for hydrogen peroxide, glucose, and uric acid

  • Xiaomei Chen
  • Genghuang Wu
  • Zhixiong Cai
  • Munetaka Oyama
  • Xi ChenEmail author
Review Article


Enzyme-free (also called non-enzymatic or direct) electrochemical sensors have been widely used for the determination of hydrogen peroxide, glucose, and uric acid. This review covers the recent progress made in this field. We also discuss the respective sensor materials which have strong effect on the electro-catalytic properties of the electrodes and govern the performance of these sensors. In addition, perspectives and current challenges of enzyme-free electrochemical sensors are outlined. Contains 142 references.


In the recent past, publications related to enzyme-free electrochemical sensors became plentiful. In this paper, we give an overview on the recent developments of enzyme-free sensors including hydrogen peroxide, glucose and uric acid sensors.


Enzyme-free Electrochemistry Hydrogen peroxide Glucose Uric acid 



This research work was financially supported by the National Basic Research Program of China (2010CB732402) and the National Nature Scientific Foundation of China (21175112, 21375112 and 21305050), which are gratefully acknowledged. Professor John Hodgkiss of The University of Hong Kong is thanked for his assistance with English.


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Xiaomei Chen
    • 1
    • 5
  • Genghuang Wu
    • 2
    • 3
  • Zhixiong Cai
    • 4
  • Munetaka Oyama
    • 5
  • Xi Chen
    • 2
    Email author
  1. 1.College of Biological EngineeringJimei UniversityXiamenChina
  2. 2.State Key Laboratory of Marine Environmental ScienceXiamen UniversityXiamenChina
  3. 3.Ningde Amperex Technology Ltd.NingdeChina
  4. 4.Ministry of Education Key Laboratory of Analysis and Detection Technology for Food SafetyFuzhou UniversityFuzhouChina
  5. 5.Department of Material Chemistry, Graduate School of EngineeringKyoto UniversityNishikyo-kuJapan

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