Microchimica Acta

, Volume 180, Issue 13–14, pp 1201–1209

Modelling the size and polydispersity of magnetic hybrid nanoparticles for luminescent sensing of oxygen

  • Marta Marín-Suárez
  • María C. Arias-Martos
  • Teresa Galeano-Díaz
  • Jorge F. Fernández-Sánchez
  • Alberto Fernández-Gutiérrez
Original Paper


We report on a strategy to model both the size (d) and the polydispersity (PdI) of magnetic oxygen-sensitive nanoparticles with a typical size of 200 nm in order to increase the surface area. The strategy is based on experimental design and Response Surface Methodology. Nanoparticles were prepared by miniemulsion solvent evaporation of solutions of poly(styrene-co-maleic anhydride). Features of this strategy include (1) a quick selection of the most important variables that govern d and PdI; (2) a better understanding of the parameters that affect the performance of the polymer; and (3) optimized conditions for the synthesis of nanoparticles of targeted d and PdI. The results were used to produce nanoparticles in sizes that range from 100 to 300 nm and with small polydispersity. The addition of a platinum porphyrin complex that acts as a luminescent probe for oxygen and of magnetite (Fe3O4) to the polymeric particles, did not affect d and PdI, thus demonstrating that this strategy simplifies their synthesis. The resulting luminescent and magnetic sensor nanoparticles respond to dissolved oxygen with sensitivity (Stern-Volmer constant) of around 35 bar−1.


Response surface methodology Experimental design Nanoparticles Oxygen sensing Size Polydispersity 

Supplementary material

604_2013_1054_MOESM1_ESM.docx (43 kb)
ESM 1(DOCX 43 kb)


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Marta Marín-Suárez
    • 1
  • María C. Arias-Martos
    • 1
  • Teresa Galeano-Díaz
    • 2
  • Jorge F. Fernández-Sánchez
    • 1
  • Alberto Fernández-Gutiérrez
    • 1
  1. 1.Department of Analytical ChemistryUniversity of GranadaGranadaSpain
  2. 2.Department of Analytical ChemistryUniversity of ExtremaduraBadajozSpain

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