Electrochemical sensor based on a carbon nanotube-modified imprinted sol–gel for selective and sensitive determination of ß2-agonists
- 380 Downloads
We describe a molecularly imprinted electrochemical sensor for selective and sensitive determination of β2-agonists. It is making use of a combination of single-wall carbon nanotubes (SWNTs) with a molecularly imprinted sol–gel. The SWNTs were introduced in order to enhance electron transport and sensitivity. The imprinted sol–gel film with its specific binding sites acts as a selective recognition element and as a preconcentrator for β2-agonists. The morphology of the imprinted film was characterized by scanning electron microscopy. The optimized sensor displays high sensitivity and excellent selectivity for the β2-agonists as shown for their determination in human serum samples.
KeywordsMolecularly imprinted polymer Single-wall carbon nanotubes Sol–gel β2-agonists
This work was financially supported by the National Natural Science Foundation of China (No. 21075029), the Natural Science Fund for Creative Research Groups of Hubei Province of China (No. 2011CDA111), and the Program for Excellent Youth Scholars of Innovative Research Team by Hubei Provincial Department of Education (T201101).
- 1.Virant FS (1997) In: Weiler JM (ed) Allergic and respiratory disease in sports medicine. Marcel Dekker Inc, New York, pp 65–66Google Scholar
- 2.Mitchell GA, Dunnavan G (1998) Illegal use of beta-adrenergic agonists in the United States. J Anim Sci 76:208Google Scholar
- 6.Lau JHW, Khoo CS, Murby JE (2004) Determination of clenbuterol, salbutamol, and cimaterol in bovine retina by electrospray ionization-liquid chromatography-tandem mass spectrometry. J AOAC Int 87:31Google Scholar
- 16.Wang JP, Pan MF, Fang GZ, Wang S (2009) Preparation of a novel molecularly imprinted polymer by a sol–gel process for on-line solid-phase extraction coupled with high performance liquid chromatography to detect trace enrofloxacin in fish and chicken samples. Microchim Acta 166:295CrossRefGoogle Scholar