Microchimica Acta

, Volume 180, Issue 11–12, pp 1005–1011 | Cite as

Electrochemical sensor based on a carbon nanotube-modified imprinted sol–gel for selective and sensitive determination of ß2-agonists

  • Wei Xu
  • Ping Liu
  • Chunhui Guo
  • Chao Dong
  • Xiuhua Zhang
  • Shengfu Wang
Original Paper


We describe a molecularly imprinted electrochemical sensor for selective and sensitive determination of β2-agonists. It is making use of a combination of single-wall carbon nanotubes (SWNTs) with a molecularly imprinted sol–gel. The SWNTs were introduced in order to enhance electron transport and sensitivity. The imprinted sol–gel film with its specific binding sites acts as a selective recognition element and as a preconcentrator for β2-agonists. The morphology of the imprinted film was characterized by scanning electron microscopy. The optimized sensor displays high sensitivity and excellent selectivity for the β2-agonists as shown for their determination in human serum samples.


A molecularly imprinted electrochemical sensor was constructed for selective and sensitive determination of β2-agonists. The optimized sensor displays high sensitivity and excellent selectivity for the β2-agonists as shown for their determination in human serum samples.

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Molecularly imprinted polymer Single-wall carbon nanotubes Sol–gel β2-agonists 



This work was financially supported by the National Natural Science Foundation of China (No. 21075029), the Natural Science Fund for Creative Research Groups of Hubei Province of China (No. 2011CDA111), and the Program for Excellent Youth Scholars of Innovative Research Team by Hubei Provincial Department of Education (T201101).

Supplementary material

604_2013_1020_MOESM1_ESM.doc (3.4 mb)
ESM 1 (DOC 3458 kb)


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Wei Xu
    • 1
  • Ping Liu
    • 1
  • Chunhui Guo
    • 1
  • Chao Dong
    • 1
  • Xiuhua Zhang
    • 1
  • Shengfu Wang
    • 1
  1. 1.Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials & Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesHubei UniversityWuhanChina

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