Microchimica Acta

, Volume 180, Issue 3–4, pp 161–186 | Cite as

Non-enzymatic electrochemical sensing of glucose

  • Guangfeng Wang
  • Xiuping He
  • Lingling Wang
  • Aixia Gu
  • Yan Huang
  • Bin Fang
  • Baoyou Geng
  • Xiaojun Zhang
Review Article


This article reviews the progress made in the past 5 years in the field of direct and non-enzymatic electrochemical sensing of glucose. Following a brief discussion of the merits and limitations of enzymatic glucose sensors, we discuss the history of unraveling the mechanism of direct oxidation of glucose and theories of non-enzymatic electrocatalysis. We then review non-enzymatic glucose electrodes based on the use of the metals platinum, gold, nickel, copper, of alloys and bimetals, of carbon materials (including graphene and graphene-based composites), and of metal-metal oxides and layered double hydroxides. This review contains more than 200 refs.


This article reviews the history of unraveling the mechanism of direct electrochemical glucose oxidation and the attempts to successfully develop non-enzymatic electrochemical glucose sensors over the past 5 years.


Non-enzymatic Glucose Electrochemical sensors 



This work was financially supported by the National Natural Science Foundation of China (20901003, 20971003, 21073001 and 21005001), the Key Project of the Chinese Ministry of Education (209060), Anhui Provincial Natural Science Foundation (1208085QB28), Natural Science Foundation of Anhui (KJ2012A139) and the Program for Innovative Research Team at Anhui Normal University.


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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Guangfeng Wang
    • 1
    • 2
    • 3
  • Xiuping He
    • 1
    • 2
    • 3
  • Lingling Wang
    • 1
    • 2
    • 3
  • Aixia Gu
    • 1
    • 2
    • 3
  • Yan Huang
    • 1
    • 2
    • 3
  • Bin Fang
    • 1
    • 2
    • 3
  • Baoyou Geng
    • 1
    • 2
    • 3
  • Xiaojun Zhang
    • 1
    • 2
    • 3
  1. 1.College of Chemistry and Materials ScienceAnhui Normal UniversityWuhuPeople’s Republic of China
  2. 2.Key Laboratory for Functional Molecular Solids of the Education Ministry of ChinaWuhuPeople’s Republic of China
  3. 3.Anhui Key Laboratory of Chem-BiosensingAnhui Normal UniversityWuhuPeople’s Republic of China

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