Microchimica Acta

, Volume 174, Issue 1–2, pp 41–46 | Cite as

Enhanced conductivity of a glassy carbon electrode modified with a graphene-doped film of layered double hydroxides for selectively sensing of dopamine

Original Paper


A strategy is presented for doping graphene into layered double hydroxide films (LDHs) as a means of improving charge transport of the LDH film in a modified glassy carbon electrode. This result in an enhanced electrocatalytic current for dopamine (DA) and a good separation of the potentials of DA, uric acid and ascorbic acid. Under selected conditions, the square wave voltammetric response of the electrode to DA is linear in the concentration range from 1.0 to 199 μM even in the presence of 0.1 mM ascorbic acid, and the detection limit is 0.3 μM at a signal-to-noise ratio of 3. The method was applied to the determination of DA in pharmaceutical injections with satisfactory results.


A strategy is presented for doping graphene into layered double hydroxide films (LDHs) as a means of improving charge transport of the LDH film in a modified glassy carbon electrode. This result in an enhanced electrocatalytic current for dopamine (DA) and the square wave voltammetric response of the electrode to DA is linear in the concentration range from 1.0 to 199 μM with the detection limit of 0.3 μM. The method was applied to the determination of DA in pharmaceutical injections with satisfactory results.


Layered double hydroxides Graphene Dopamine Modified electrode Composite film 



This work is supported by National Natural Science Foundation of China (Grant Nos. 20801001, 21055001, and 21075001) and Anhui Provincial Natural Science Foundation (Grant No. 11040606 M46). We also deeply appreciate the support of the foundation for doctor science research of Anhui Normal University.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Key Laboratory of Chemo − Biosensing, Anhui Province; College of Chemistry and Materials ScienceAnhui Normal UniversityWuhuChina

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