Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination
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An electrochemical sensor for theophylline (ThPh) was prepared by electropolymerizing o-phenylenediamine on a glassy carbon electrode in the presence of ThPh via cyclic voltammetry, followed by deposition of gold nanoparticles using a potentiostatic method. The effects of pH, ratio between template molecule and monomer, number of cycles for electropolymerization, and of the solution for extraction were optimized. The current of the electro-active model system hexacyanoferrate(III) and hexacyanoferrate(IV) decreased linearly with successive addition of ThPh in the concentration range between 4.0 × 10−7 ~ 1.5 × 10−5 mol·L−1 and 2.4 × 10−4 ~ 3.4 × 10−3 mol·L−1, with a detection limit of 1.0 × 10−7 mol·L−1. The sensor has an excellent recognition capability for ThPh compared to structurally related molecules, can be regenerated and is stable.