Microchimica Acta

, Volume 170, Issue 3–4, pp 193–214 | Cite as

Biosensors based on cholinesterase inhibition for insecticides, nerve agents and aflatoxin B1 detection (review)

  • Fabiana Arduini
  • Aziz Amine
  • Danila Moscone
  • Giuseppe Palleschi
Review Article


The present review reports the research carried out during last 9 years on biosensors based on cholinesterase inhibition for nerve agents, organophosphorus and carbammic insecticides, and aflatoxin B1 detection. Relative applications in environmental and food areas are also reported. Special attention is paid to the optimization of parameters such as enzyme immobilization, substrate concentration, and incubation time in the case of reversible inhibition by aflatoxin B1 or irreversible inhibition by organophosphorus and carbamic insecticides, and nerve agents in order to optimize and improve the analytical performances of the biosensor. Evaluation of selectivity of the system is also discussed.


Biosensors Inhibition Insecticides Cholinesterase Nerve agents Aflatoxin 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Fabiana Arduini
    • 1
    • 2
  • Aziz Amine
    • 3
  • Danila Moscone
    • 1
    • 2
  • Giuseppe Palleschi
    • 1
    • 2
  1. 1.Dipartimento di Scienze e Tecnologie ChimicheUniversità di Roma Tor VergataRomeItaly
  2. 2.Consorzio Interuniversitario Biostrutture e Biosistemi “INBB”RomeItaly
  3. 3.Faculté des Sciences et TechniquesMohammadiaMorocco

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