Microchimica Acta

, Volume 168, Issue 1–2, pp 87–92 | Cite as

Enzyme-free amperometric sensing of glucose using Cu-CuO nanowire composites

  • Guangfeng Wang
  • Yan Wei
  • Wei Zhang
  • Xiaojun Zhang
  • Bin Fang
  • Lun WangEmail author
Original Paper


A non-enzymatic amperometric glucose is reported that is based on an glassy carbon electrode modified with a Cu-CuO nanowire (NW) composite. The morphology and the composition of the nanowire were characterized by scanning electron microscopy and X-ray diffraction, respectively. The modified electrode efficiently catalyzes the oxidation of glucose at less-positive potential (0.30 V) in 0.10 M NaOH solution in the absence of any enzymes or redox mediators. The sensor was successfully used for the amperometric sensing of glucose. Linear response was obtained over the concentration range from 0.1 to 12 mM. The common interfering agents ascorbic acid and uric acid do not interfere with the determination of glucose. The modified electrode features high sensitivity, low working potential, excellent stability, and fast amperometric sensing of glucose. Thus it is promising for the future development of non-enzymatic glucose sensors.


CuO nanowire Glucose Electrocatalysis Enzyme-free Amperometric detection 



This work was supported by the National Natural Science Foundation of China (No.20675001, 20901003), Anhui Key Laboratory of Controllable Chemistry Reaction & Material Chemical Engineering, the Young Teacher Program of Anhui Normal University (2009xqnzc19), and the Natural Science Foundation of Educational Department of Anhui Province (No. KJ2008B167, No. KJ2009B013Z).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Guangfeng Wang
    • 1
    • 2
  • Yan Wei
    • 1
    • 2
  • Wei Zhang
    • 1
    • 2
  • Xiaojun Zhang
    • 3
  • Bin Fang
    • 1
    • 2
  • Lun Wang
    • 1
    • 2
    Email author
  1. 1.Key Laboratory of Chem-BiosensingAnhui Normal UniversityWuhuPeople’s Republic of China
  2. 2.College of Chemistry and Materials ScienceAnhui Normal UniversityWuhuPeople’s Republic of China
  3. 3.Anhui Key Laboratory of Functional Molecular SolidsAnhui Normal UniversityWuhuPeople’s Republic of China

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