Microchimica Acta

, Volume 153, Issue 3–4, pp 127–131 | Cite as

Fluororeactands for the Detection of Saccharides Based on Hemicyanine Dyes with a Boronic Acid Receptor

  • Sabine Trupp
  • Annika Schweitzer
  • Gerhard J. Mohr
Original Paper


Three hemicyanine dyes with boronic acid receptor functions have been synthesized in a two step procedure. These dyes are capable of forming a covalent bond between their boronic acid moiety and the diol moiety of saccharides which causes fluorescence to change. In detail, the indicator dyes exhibit absorbance maxima at around 460 nm and emission at around 600 nm, show increases in fluorescence upon exposure to saccharides and can be used in aqueous solution at physiological pH.

Key words: Fluororeactand; hemicyanine dyes; saccharides. 


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  1. DiCesare, N, Lakowicz, J R 2001Chem Commun192022Google Scholar
  2. Badugu, R, Lakowicz, J R, Geddes, C D 2004Anal Chem76610CrossRefGoogle Scholar
  3. Badugu, R, Lakowicz, J R, Geddes, C D 2003J Fluoresc13371CrossRefGoogle Scholar
  4. Suri, J T, Cordes, D B, Cappuccio, F E, Wessling, R A, Singaram, B 2003Angew Chem1156037CrossRefGoogle Scholar
  5. Arimori, S, Phillips, M D, James, T D 2004Tetrahedron Letters451539CrossRefGoogle Scholar
  6. Cao, H, Heagy, M D 2004J Fluoresc14569CrossRefGoogle Scholar
  7. Mohr, G J 2004Chem Eur J101083CrossRefGoogle Scholar
  8. Mohr, G J, Demuth, C, Spichiger-Keller, U E 1998Anal Chem703868CrossRefGoogle Scholar
  9. Mohr, G J, Spichiger-Keller, U E, Jona, W, Langhals, H 2000Anal Chem721084CrossRefGoogle Scholar
  10. Hassner, A, Birnbaum, D, Loew, L M J 1984Org Chem492546Google Scholar
  11. Fromherz, P, Muller, C O 1993Biochim Biophys Acta1150111Google Scholar
  12. Bullen, A, Saggau, P 1999Biophysical J762272CrossRefGoogle Scholar
  13. Mujumdar, R B, Ernst, L A, Mujumdar, S R, Lewis, C J, Waggoner, A S 1993Bioconj Chem4105Google Scholar
  14. Wetzl, B, Gruber, M, Oswald, B, Durkop, A, Weidgans, B, Probst, M, Wolfbeis, O S 2003J Chromatogr B79383CrossRefGoogle Scholar
  15. Czerney, P, Lehmann, F, Wenzel, M, Buschmann, V, Dietrich, A, Mohr, G J 2001Biol Chem382495CrossRefGoogle Scholar
  16. Suri, J T, Cordes, D B, Cappuccio, F E, Wessling, R A, Singaram, B 2003Langmuir195145CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2006

Authors and Affiliations

  • Sabine Trupp
    • 1
  • Annika Schweitzer
    • 1
  • Gerhard J. Mohr
    • 1
  1. 1.Institute of Physical Chemistry, Friedrich-Schiller-University JenaJenaGermany

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