Chemokines, receptors, and their role in cardiovascular pathology

  • J. M. Wang
  • S. Su
  • J. J. Oppenheim
  • W. Gong
Review

DOI: 10.1007/s005990050024

Cite this article as:
Wang, J.M., Su, S., Oppenheim, J.J. et al. Int J Clin Lab Res (1998) 28: 83. doi:10.1007/s005990050024

Abstract

A superfamily of leukocyte chemotactic proteins, known as chemokines, has been identified during the past decade. Chemokines selectively attract and activate different leukocyte subpopulations and are key mediators of a variety of patho-physiological states, including hematopoiesis, inflammation, infection, allergy, atheroslerosis, reperfusion injury, as well as malignant tumors. Chemokines bind and activate a number of specific or promiscuous, G-protein-coupled seven-transmembrane receptors. Some of these receptors are utilized by human immuno-deficiency virus type 1 as essential fusion co-factors. Further understanding of the role of chemokines and their receptors in host defense will help develop means by which the beneficial versus detrimental effects of these molecules can be balanced.

Key words

Chemokines Receptors Atherosclerosis Reperfusion 

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • J. M. Wang
    • 1
  • S. Su
    • 1
  • J. J. Oppenheim
    • 1
  • W. Gong
    • 2
  1. 1.Laboratory of Molecular Immunoregulation, Division of Basic SciencesNational Cancer Institute-Frederick Cancer Research and Development CenterFrederickUSA
  2. 2.Intramural Research Support Program, SAIC Frederick, National Cancer InstituteFrederick Cancer Research and Development CenterFrederickUSA

Personalised recommendations