Surgery Today

, Volume 32, Issue 7, pp 602–607

Significance of Serum Endotoxin and Antiendotoxin Antibody Levels in Predicting the Severity of Acute Pancreatitis

  • Shashanka Mohan Bose
  • Ganga Ram Verma
  • Alok Mazumdar
  • M. Giridhar
  • Nirmal Kumar Ganguly

DOI: 10.1007/s005950200109

Cite this article as:
Bose, S., Verma, G., Mazumdar, A. et al. Surg Today (2002) 32: 602. doi:10.1007/s005950200109

Abstract.

Abstract.

Purpose:

A close association between endotoxemia and acute pancreatitis has been reported, and attempts have been made to predict the severity of pancreatitis by estimating the levels of endotoxin. The present study was designed to correlate endotoxemia with the severity and complications of acute pancreatitis as graded by contrast-enhanced computed tomography and Blamey's criteria.

Methods:

We examined 20 patients with acute pancreatitis, using Blamey's criteria to assess the severity of pancreatitis. The endotoxin level was estimated by the Limulus Amoebocyte Lysate method and the antiendotoxin antibody level was assayed by the enzyme-linked immunoassay technique measuring combined levels of IgG and IgM.

Results:

Severe pancreatitis was confirmed in 9 of the 20 patients, 17 (85%) of whom were found to have endotoxemia. There was no correlation between the presence and level of endotoxemia and the severity of pancreatitis; however, antiendotoxin antibody titers were significantly lower in patients with severe disease (P < 0.05), those who suffered of major complications (P < 0.01), and those who died of the disease (P < 0.01).

Conclusion:

The findings of this study demonstrated that the presence of endotoxemia accompanied by a fall in antiendotoxin antibody titer predicts poor outcome in patients with acute pancreatitis.

Key words Acute pancreatitis Endotoxemia Antiendotoxin antibody 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Shashanka Mohan Bose
    • 1
  • Ganga Ram Verma
    • 1
  • Alok Mazumdar
    • 1
  • M. Giridhar
    • 1
  • Nirmal Kumar Ganguly
    • 2
  1. 1.Departments of Surgery andIN
  2. 2.Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, IndiaIN

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