The Prognostic Value of Quality-of-Life Scores: Preliminary Results of an Analysis of Patients with Breast Cancer
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This study was conducted to elucidate the prognostic value of patient-assessed quality-of-life (QL) scores in cancer patients. QL was assessed in 47 consecutive patients with advanced or end-stage breast cancer using the Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD). The data collected from 19 of the 47 patients, who completed QL questionnaires more than twice before dying of cancer, were analyzed. The relationships between the QL scores and subsequent survival were examined at two assessment points, being the first and last assessment points of each of the 19 patients; corresponding respectively to median survival times of 14 and 4 months. The prognostic significance of the changes in QL scores that occurred over 3 months before the last assessment point was also examined. At the last assessment point, the scores of the physical aspects of QL were significantly related to survival. The change in scores of both overall QL and the physical aspects of QL were also significant predictors of survival. On the other hand, neither the scores nor the change in scores of the psychological and social aspects of QL was significant. This study indicates that both QL scores and changes in QL scores are promising prognostic predictors.
Key Wordsbreast cancer prognosis quality of life palliative care
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- 4.Shimozuma K, Tominaga T, Hayashi K, Kondo J, Kosaki G (1991) Notification of cancer in breast cancer patients (in Japanese with English abstract). Jpn J Cancer Chemother 18:2147–2153Google Scholar
- 5.Shimozuma K, Tominaga T, Hayashi K, Kosaki G (1991) Evaluation of quality of life in breast cancer patients (in Japanese with English abstract). J Jpn Soc Cancer Ther 26:1504–1510Google Scholar
- 13.Ruckdeschel JC, Piantadosi S, and the Lung Cancer Study Group (1991) Quality of life assessment in lung surgery for bronchogenic carcinoma. J Theor Surg 6:201–205Google Scholar
- 15.Shimozuma K, Sonoo H, Ichihara K (1995) Analysis of factors that improve quality of life of patients with advanced or recurrent breast cancer (in Japanese with English abstract). Jpn J Cancer Chemother 22:1095–1102Google Scholar
- 16.Shimozuma K, Sonoo H, Tanaka K, Ichihara K (1997) Analysis of factors that improve quality-of-life of patients with advanced or recurrent breast cancer (in Japanese with English abstract). Jpn J Breast Cancer 12:58–67Google Scholar
- 17.Eguchi K, Kurihara M, Shimozuma K, Hotta T, Murakami M, Suzuki N, Ishikawa K, Ogawa H, Tominaga T, Kobayashi K, Shimizu H, Tsuboi K (1993) The QOL questionnaire for cancer patients treated with anticancer drugs (in Japanese). J Jpn Soc Cancer Ther 28:1140–1144Google Scholar
- 20.Zubrod CG, Schneiderman M, Frei E III, Brindley C, Gold GL, Shnider B, Oviedo R, Gorman J, Jones R, Jonsson U, Colsky J, Chalmers T, Ferguson B, Dederick M, Holland J, Selawry O, Regelson W, Lasagna L, Owens AH Jr (1960) Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11:7–33CrossRefGoogle Scholar
- 21.Union Internationale Contre le Cancer, Breast (ICD-O 174) (1987) In: Harmer MH (ed) TNM classification of malignant tumours, 4th edn. Springer, Berlin, pp 93–99Google Scholar
- 23.Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de-Haes JC, Kaasa S, Klee M, Osoba D, Razavi D, Rofe PB, Schraub S, Sneeuw K, Sullivan M, Takeda F for the European Organization for Research and Treatment of Cancer Group on Quality of Life (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natal Cancer Inst 85:365–376CrossRefGoogle Scholar
- 27.Coates AS, Dillenbeck CF, McNeil DR, Kaye SB, Sims K, Fox RM, Woods RL, Milton GW, Solomon J, Tattersall MH (1983) On the receiving end — II. Linear analog self assessment (LASA) in evaluation of aspects of the quality of life of cancer patients receiving therapy. Eur J Cancer Clin Oncol 19:1633–1637PubMedCrossRefGoogle Scholar