Clinical and prognostic differences between surgically resected right-sided and left-sided colorectal cancer

  • Koji FukataEmail author
  • Norihiro Yuasa
  • Eiji Takeuchi
  • Hideo Miyake
  • Hidemasa Nagai
  • Yuichiro Yoshioka
  • Kanji Miyata
Original Article



A growing body of evidence suggests that right-sided colorectal cancer (RCRC) differs from left-sided colorectal cancer (LCRC) in certain clinicopathological features. Therefore, we investigated the difference between RCRC and LCRC in a series of 899 patients.


We reviewed data retrospectively, from 899 patients who underwent R0-resection for stage II and III CRC and compared the clinicopathological factors between patients with RCRC and LCRC.


The patients with RCRC tended to be older, more likely female, with a larger tumor, higher pathological T stage, and a greater proportion of their tumors were poorly differentiated adenocarcinoma, mucinous adenocarcinoma, or signet ring cell carcinoma than the patients with LCRC,. Recurrence-free survival (RFS) of the patients with RCRC tended to be higher than that of the patients with LCRC and was significantly better among patients with stage II cancer. The overall survival (OS) was similar for patients with RCRC and LCRC, irrespective of cancer stage.


Compared with the patients with LCRC, those with RCRC had several oncologically unfavorable factors, with better RFS in stage II and similar OS in stages II and III. These results suggest that the biological aggressiveness of RCRC is lower than that of LCRC in stage II; however, it can increase after relapse.


Colorectal cancer Right-sided colon Prognosis 


Compliance with ethical standards

Conflict of interest

We have no conflicts of interest to declare.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Koji Fukata
    • 1
    Email author
  • Norihiro Yuasa
    • 1
  • Eiji Takeuchi
    • 1
  • Hideo Miyake
    • 1
  • Hidemasa Nagai
    • 1
  • Yuichiro Yoshioka
    • 1
  • Kanji Miyata
    • 1
  1. 1.Department of Gastrointestinal SurgeryJapanese Red Cross Nagoya First HospitalNagoyaJapan

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