Surgery Today

, Volume 50, Issue 1, pp 68–75 | Cite as

Efficacy and safety of enoxaparin for preventing venous thromboembolic events after laparoscopic colorectal cancer surgery: a randomized-controlled trial (YCOG 1404)

  • Kazuya Nakagawa
  • Jun WatanabeEmail author
  • Mitsuyoshi Ota
  • Yusuke Suwa
  • Shinsuke Suzuki
  • Hirokazu Suwa
  • Masashi Momiyama
  • Atsushi Ishibe
  • Yusuke Saigusa
  • Takeharu Yamanaka
  • Chikara Kunisaki
  • Itaru Endo
Original Article



We conducted a prospective study to evaluate the efficacy and safety of postoperative enoxaparin for the prevention of venous thromboembolism (VTE) after laparoscopic surgery for colorectal cancer (LAC) in Japanese patients.


The subjects of this multicenter, open-label randomized-controlled trial were 121 patients who underwent LAC between September 2015 and May 2017. The patients were randomly allocated to receive intermittent pneumatic compression (IPC) with enoxaparin (20 mg, twice daily), started 24–36 h after surgery and continued until discharge (Enoxaparin group; n = 61), or IPC alone (IPC group; n = 60). The primary endpoint was the incidence of VTE on day 28 after surgery. The safety outcome was the incidence of any bleeding during treatment and follow-up.


The incidence of VTE on day 28 after surgery was 12.3% (7/57 patients) in the enoxaparin group and 11.9% (7/59 patients) in the IPC group ((p = 1.00). One of the 57 patients (1.8%) in the enoxaparin group and none in the IPC group experienced a bleeding event.


It may be unnecessary to give enoxaparin to all Japanese patients for the prevention of VTE after LAC.

The UMIN Clinical Trials Registry number was UMIN000018633.


Colorectal cancer Laparoscopic surgery Enoxaparin Venous thromboembolism Thromboprophylaxis 


Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest or financial ties to disclose.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Kazuya Nakagawa
    • 1
  • Jun Watanabe
    • 2
    Email author
  • Mitsuyoshi Ota
    • 1
  • Yusuke Suwa
    • 1
  • Shinsuke Suzuki
    • 1
  • Hirokazu Suwa
    • 3
  • Masashi Momiyama
    • 1
  • Atsushi Ishibe
    • 1
  • Yusuke Saigusa
    • 4
  • Takeharu Yamanaka
    • 4
  • Chikara Kunisaki
    • 2
  • Itaru Endo
    • 1
  1. 1.Department of Gastroenterological SurgeryYokohama City University Graduate School of MedicineYokohamaJapan
  2. 2.Department of Surgery, Gastroenterological CenterYokohama City University Medical CenterYokohamaYokohamaJapan
  3. 3.Department of SurgeryYokosuka Kyosai HospitalYokosukaJapan
  4. 4.Department of BiostatisticsYokohama City University Graduate School of MedicineYokohamaJapan

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