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Prognostic predictions based on pathological findings of peritoneal dissemination in patients with stage IV colorectal cancer without residual disease (R0 status)

  • Koji KomoriEmail author
  • Takashi Kinoshita
  • Taihei Oshiro
  • Akira Ouchi
  • Seiji Ito
  • Tetsuya Abe
  • Yoshiki Senda
  • Kazunari Misawa
  • Yuichi Ito
  • Seiji Natsume
  • Eiji Higaki
  • Masataka Okuno
  • Takahiro Hosoi
  • Byonggu An
  • Daisuke Hayashi
  • Tairin Uchino
  • Aina Kunitomo
  • Satoshi Oki
  • Jin Takano
  • Yasuhito Suenaga
  • Shingo Maeda
  • Hideyuki Dei
  • Yoshihisa Numata
  • Yasuhiro Shimizu
Original Article
  • 22 Downloads

Abstract

Purpose

This study aimed to clarify the prognosis of patients after resection of stage IV colorectal cancer and synchronous peritoneal metastasis (no residual disease: R0 status) based on histopathologic findings.

Methods

The subjects of this study were 26 patients who underwent radical resection of synchronous peritoneal metastases of stage IV colorectal cancer. Only patients with one synchronous peritoneal metastasis were included in this study. The peritoneal lesions were initially classified into two categories based on the presence or absence of adenocarcinoma on their surface: RM-negative or RM-positive. The lesions were subsequently classified as being of massive or diffuse type and of small (< 6 mm) or large (≥ 6 mm) type according to the maximum metastatic tumor dimension.

Results

Multivariate analysis revealed that massive type metastatic tumors were associated with a better disease-free survival (DFS; p = 0.047) and overall survival (OS; p = 0.033), than diffuse type tumors.

Conclusion

A detailed stratification of pathological findings could contribute remarkably to prognostic predictions for patients with synchronous peritoneal metastases.

Keywords

peritoneal metastasis Stage IV R0 status 

Notes

Compliance with ethical standards

Ethical standards

This research project was approved by the Ethics Committee of our institution (2018-1-137) and conformed to the provisions of the Declaration of Helsinki.

Conflict of interest

We have no conflicts of interest to declare in relation to this study.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Koji Komori
    • 1
    Email author
  • Takashi Kinoshita
    • 1
  • Taihei Oshiro
    • 1
  • Akira Ouchi
    • 1
  • Seiji Ito
    • 1
  • Tetsuya Abe
    • 1
  • Yoshiki Senda
    • 1
  • Kazunari Misawa
    • 1
  • Yuichi Ito
    • 1
  • Seiji Natsume
    • 1
  • Eiji Higaki
    • 1
  • Masataka Okuno
    • 1
  • Takahiro Hosoi
    • 1
  • Byonggu An
    • 1
  • Daisuke Hayashi
    • 1
  • Tairin Uchino
    • 1
  • Aina Kunitomo
    • 1
  • Satoshi Oki
    • 1
  • Jin Takano
    • 1
  • Yasuhito Suenaga
    • 1
  • Shingo Maeda
    • 1
  • Hideyuki Dei
    • 1
  • Yoshihisa Numata
    • 1
  • Yasuhiro Shimizu
    • 1
  1. 1.Department of Gastroenterological SurgeryAichi Cancer Center HospitalNagoyaJapan

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