Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review
- 102 Downloads
To investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.
The subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in “the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan” database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.
Thyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17–41 years and 39–57 years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of < 33 years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.
FAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20 s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20 s.
KeywordsFamilial adenomatous polyposis Meta-analysis Prevalence Risk factor Thyroid cancer
We appreciate the support with our statistical analyses, given by Minoru Hattori, Advanced Medical Skills Training Center, Hiroshima University, and we thank the Japanese Society for Cancer of Colon and Rectum (JSCCR) for their cooperation.
Compliance with ethical standards
Conflict of interest
We have no conflicts of interest to declare.
- 4.Burn J, Chapman P, Delhanty J, Wood C, Lalloo F, Cachon-Gonzalez MB, et al. The UK Northern region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium, and DNA markers in risk calculations. J Med Genet. 1991;28:289–96.CrossRefGoogle Scholar
- 7.HJR B. Familial polyposis coli. Baltimore: Johns Hopkins University Press; 1975.Google Scholar
- 22.Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, et al. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol. 2007;5:367–73. https://doi.org/10.1016/j.cgh.2006.10.019.CrossRefPubMedGoogle Scholar
- 24.Steinhagen E, Guillem JG, Chang G, Salo-Mullen EE, Shia J, Fish S, et al. The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. Clin Colorectal Cancer. 2012;11:304–8. https://doi.org/10.1016/j.clcc.2012.01.006.CrossRefPubMedGoogle Scholar
- 27.Ueno H, Kobayashi H, Konishi T, Ishida F, Yamaguchi T, Hinoi T, et al. Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan. Int J Clin Oncol. 2016;21:713–22. https://doi.org/10.1007/s10147-016-0953-5.CrossRefPubMedGoogle Scholar
- 31.Matsuda A, Matsuda T, Shibata A, Katanoda K, Sobue T, Nishimoto H, et al. Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol. 2014;44:388–96. https://doi.org/10.1093/jjco/hyu003.CrossRefPubMedGoogle Scholar
- 32.Kennedy RD, Potter DD, Moir CR, El-Youssef M. The natural history of familial adenomatous polyposis syndrome: a 24 year review of a single center experience in screening, diagnosis, and outcomes. J Pediatr Surg. 2014;49:82–6. https://doi.org/10.1016/j.jpedsurg.2013.09.033.CrossRefPubMedGoogle Scholar