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Surgery Today

, Volume 49, Issue 1, pp 72–81 | Cite as

Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

  • Haruki Sada
  • Takao HinoiEmail author
  • Hideki Ueno
  • Tatsuro Yamaguchi
  • Yasuhiro Inoue
  • Tsuyoshi Konishi
  • Hirotoshi Kobayashi
  • Yukihide Kanemitsu
  • Fumio Ishida
  • Hideyuki Ishida
  • Naohiro Tomita
  • Nagahide Matsubara
  • Kenichi Sugihara
Original Article
  • 102 Downloads

Abstract

Purpose

To investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.

Methods

The subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in “the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan” database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.

Results

Thyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17–41 years and 39–57 years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of < 33 years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.

Conclusions

FAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20 s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20 s.

Keywords

Familial adenomatous polyposis Meta-analysis Prevalence Risk factor Thyroid cancer 

Notes

Acknowledgements

We appreciate the support with our statistical analyses, given by Minoru Hattori, Advanced Medical Skills Training Center, Hiroshima University, and we thank the Japanese Society for Cancer of Colon and Rectum (JSCCR) for their cooperation.

Compliance with ethical standards

Conflict of interest

We have no conflicts of interest to declare.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Haruki Sada
    • 1
  • Takao Hinoi
    • 1
    • 12
    Email author
  • Hideki Ueno
    • 2
  • Tatsuro Yamaguchi
    • 3
  • Yasuhiro Inoue
    • 4
  • Tsuyoshi Konishi
    • 5
  • Hirotoshi Kobayashi
    • 6
  • Yukihide Kanemitsu
    • 7
  • Fumio Ishida
    • 8
  • Hideyuki Ishida
    • 9
  • Naohiro Tomita
    • 10
  • Nagahide Matsubara
    • 10
  • Kenichi Sugihara
    • 11
  1. 1.Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of SurgeryNational Defense Medical CollegeSaitamaJapan
  3. 3.Department of SurgeryTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  4. 4.Department of Gastrointestinal and Pediatric SurgeryMie University Graduate School of MedicineTsuJapan
  5. 5.Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyoJapan
  6. 6.Department of SurgeryTokyo Metropolitan Hiroo HospitalTokyoJapan
  7. 7.Division of Colorectal SurgeryNational Cancer Center HospitalTokyoJapan
  8. 8.Digestive Disease CenterShowa University Northern Yokohama HospitalYokohamaJapan
  9. 9.Department of Digestive Tract and General Surgery, Saitama Medical CenterSaitama Medical UniversitySaitamaJapan
  10. 10.Division of Lower GI Surgery, Department of SurgeryHyogo College of MedicineNishinomiyaJapan
  11. 11.Tokyo Medical and Dental UniversityTokyoJapan
  12. 12.Department of Surgery, Institute for Clinical ResearchNational Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshimaJapan

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