Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

  • Masashi Miguchi
  • Takao Hinoi
  • Kohji Tanakaya
  • Tatsuro Yamaguchi
  • Yoichi Furukawa
  • Teruhiko Yoshida
  • Kazuo Tamura
  • Kokichi Sugano
  • Chikashi Ishioka
  • Nagahide Matsubara
  • Naohiro Tomita
  • Masami Arai
  • Hideki Ishikawa
  • Keiji Hirata
  • Yoshihisa Saida
  • Hideyuki Ishida
  • Kenichi Sugihara
Short Communication
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Abstract

We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13–5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38–1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS

Key words

Lynch syndrome Alcohol Colorectal cancer 
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Notes

Conflict of interest

We have no conflicts of interest to declare.

References

  1. 1.
    Samowitz WS, Curtin K, Lin HH, Robertson MA, Schaffer D, Nichols M, et al. The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. Gastroenterology. 2001;121:830–8.CrossRefPubMedGoogle Scholar
  2. 2.
    Mitchell RJ, Farrington SM, Dunlop MG, Campbell H. Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review. Am J Epidemiol. 2002;156:885–902.CrossRefPubMedGoogle Scholar
  3. 3.
    Potter JD. At the interfaces of epidemiology, genetics and genomics. Nat Rev Genet. 2001;2:142–7.CrossRefPubMedGoogle Scholar
  4. 4.
    Win AK, Dowty JG, English DR, Campbell PT, Young JP, Winship I, et al. Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Br J Cancer. 2011;105:162–9.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Ait Ouakrim D, Dashti SG, Chau R, Buchanan DD, Clendenning M, Rosty C, et al. Aspirin, ibuprofen, and the risk of colorectal cancer in Lynch syndrome. J Natl Cancer Inst. 2015; 107.Google Scholar
  6. 6.
    Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008; 67: 253–6.CrossRefPubMedGoogle Scholar
  7. 7.
    Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, et al. Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2003;12:1492 – 500.PubMedGoogle Scholar
  8. 8.
    Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, et al. Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center. Clin Cancer Res. 2010;16:1331–9.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Winkels RM, Botma A, Van Duijnhoven FJ, Nagengast FM, Kleibeuker JH, Vasen HF, et al. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome. Gastroenterology. 2012;142:241–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, et al. Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Jpn J Clin Oncol. 2015;45:307 – 10.CrossRefPubMedGoogle Scholar
  11. 11.
    Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, et al. Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Jpn J Clin Oncol. 2015;45:153–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Tanakaya K, Yamaguchi T, Ishikawa H, Hinoi T, Furukawa Y, Hirata K, et al. Causes of cancer death among first-degree relatives in Japanese Families with Lynch syndrome. Anticancer Res. 2016;36:1985–9.PubMedGoogle Scholar
  13. 13.
    Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A. Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Delta468 min mouse model of colon cancer. Alcohol Clin Exp Res. 2013;37(Suppl 1):E199–E208.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Roy HK, Gulizia JM, Karolski WJ, Ratashak A, Sorrell MF, Tuma D. Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev. 2002;11:1499–502.PubMedGoogle Scholar
  15. 15.
    Hsing AW, McLaughlin JK, Chow WH, Schuman LM, Co Chien HT, Gridley G, et al. Risk factors for colorectal cancer in a prospective study among U.S. white men. Int J Cancer. 1998;77:549–53.CrossRefPubMedGoogle Scholar
  16. 16.
    Flood A, Caprario L, Chaterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States. Cancer Causes Control. 2002;13:551–61.CrossRefPubMedGoogle Scholar
  17. 17.
    Glynn SA, Albanes D, Pietinen P, Brown CC, Rautalahti M, Tangrea JA, et al. Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control. 1996;7:214–23.CrossRefPubMedGoogle Scholar
  18. 18.
    Longnecker MP, Orza MJ, Adams ME, Vioque J, Chalmers TC. A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control. 1990;1:59–68.CrossRefPubMedGoogle Scholar
  19. 19.
    Pedersen A, Johansen C, Gronbaek M. Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study. Gut. 2003;52:861–7.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Diergaarde B, Braam H, Vasen HF, Nagengast FM, van Muijen GN, Kok FJ, et al. Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol. 2007;5:736 – 42.CrossRefPubMedGoogle Scholar
  21. 21.
    Watson P, Vasen HF, Mecklin JP, Bernstein I, Aarnio M, Jarvinen HJ, et al. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer. 2008;123:444–9.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet. 2011;378:2081–7.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Masashi Miguchi
    • 1
  • Takao Hinoi
    • 1
  • Kohji Tanakaya
    • 2
  • Tatsuro Yamaguchi
    • 3
  • Yoichi Furukawa
    • 4
  • Teruhiko Yoshida
    • 5
  • Kazuo Tamura
    • 6
  • Kokichi Sugano
    • 7
  • Chikashi Ishioka
    • 8
  • Nagahide Matsubara
    • 9
  • Naohiro Tomita
    • 9
  • Masami Arai
    • 10
  • Hideki Ishikawa
    • 11
  • Keiji Hirata
    • 12
  • Yoshihisa Saida
    • 13
  • Hideyuki Ishida
    • 14
  • Kenichi Sugihara
    • 15
  1. 1.Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of SurgeryIwakuni Clinical CenterYamaguchiJapan
  3. 3.Department of SurgeryTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  4. 4.Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical ScienceThe University of TokyoTokyoJapan
  5. 5.Division of GeneticsNational Cancer Center Research InstituteTokyoJapan
  6. 6.Major in Science, Graduate School of Science and Engineering ResearchKinki UniversityHigashiosakaJapan
  7. 7.Oncogene Research Unit/Cancer Prevention UnitTochigi Cancer Center Research InstituteUtsunomiyaJapan
  8. 8.Department of Clinical Oncology, Institute of Development, Aging and CancerTohoku UniversitySendaiJapan
  9. 9.Department of SurgeryHyogo College of MedicineNishinomiyaJapan
  10. 10.Clinical Genetic OncologyCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan
  11. 11.Department of Molecular-Targeting Cancer PreventionKyoto Prefectural University of MedicineKyotoJapan
  12. 12.Department of Surgery 1University of Occupational and Environmental HealthKitakyushuJapan
  13. 13.Department of SurgeryToho University Ohashi Medical CenterTokyoJapan
  14. 14.Department of Digestive Tract and General Surgery, Saitama Medical CenterSaitama Medical UniversityKawagoeJapan
  15. 15.Tokyo Medical and Dental UniversityTokyoJapan

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