Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

  • Masashi Miguchi
  • Takao Hinoi
  • Kohji Tanakaya
  • Tatsuro Yamaguchi
  • Yoichi Furukawa
  • Teruhiko Yoshida
  • Kazuo Tamura
  • Kokichi Sugano
  • Chikashi Ishioka
  • Nagahide Matsubara
  • Naohiro Tomita
  • Masami Arai
  • Hideki Ishikawa
  • Keiji Hirata
  • Yoshihisa Saida
  • Hideyuki Ishida
  • Kenichi Sugihara
Short Communication
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Abstract

We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13–5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38–1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS

Key words

Lynch syndrome Alcohol Colorectal cancer 

Notes

Conflict of interest

We have no conflicts of interest to declare.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Masashi Miguchi
    • 1
  • Takao Hinoi
    • 1
  • Kohji Tanakaya
    • 2
  • Tatsuro Yamaguchi
    • 3
  • Yoichi Furukawa
    • 4
  • Teruhiko Yoshida
    • 5
  • Kazuo Tamura
    • 6
  • Kokichi Sugano
    • 7
  • Chikashi Ishioka
    • 8
  • Nagahide Matsubara
    • 9
  • Naohiro Tomita
    • 9
  • Masami Arai
    • 10
  • Hideki Ishikawa
    • 11
  • Keiji Hirata
    • 12
  • Yoshihisa Saida
    • 13
  • Hideyuki Ishida
    • 14
  • Kenichi Sugihara
    • 15
  1. 1.Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of SurgeryIwakuni Clinical CenterYamaguchiJapan
  3. 3.Department of SurgeryTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  4. 4.Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical ScienceThe University of TokyoTokyoJapan
  5. 5.Division of GeneticsNational Cancer Center Research InstituteTokyoJapan
  6. 6.Major in Science, Graduate School of Science and Engineering ResearchKinki UniversityHigashiosakaJapan
  7. 7.Oncogene Research Unit/Cancer Prevention UnitTochigi Cancer Center Research InstituteUtsunomiyaJapan
  8. 8.Department of Clinical Oncology, Institute of Development, Aging and CancerTohoku UniversitySendaiJapan
  9. 9.Department of SurgeryHyogo College of MedicineNishinomiyaJapan
  10. 10.Clinical Genetic OncologyCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan
  11. 11.Department of Molecular-Targeting Cancer PreventionKyoto Prefectural University of MedicineKyotoJapan
  12. 12.Department of Surgery 1University of Occupational and Environmental HealthKitakyushuJapan
  13. 13.Department of SurgeryToho University Ohashi Medical CenterTokyoJapan
  14. 14.Department of Digestive Tract and General Surgery, Saitama Medical CenterSaitama Medical UniversityKawagoeJapan
  15. 15.Tokyo Medical and Dental UniversityTokyoJapan

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