Surgery Today

, Volume 48, Issue 5, pp 486–494 | Cite as

Development of a new surgical sheet containing both silk fibroin and thermoplastic polyurethane for cardiovascular surgery

  • Ryo Shimada
  • Hayato Konishi
  • Hideki Ozawa
  • Takahiro Katsumata
  • Ryou Tanaka
  • Yasumoto Nakazawa
  • Shintaro Nemoto
Original Article
First Online:
Received:
Accepted:
  • 167 Downloads

Abstract

Purpose

The surgical sheets that are currently used for congenital cardiovascular surgery have several drawbacks, including material deterioration, calcification, and pseudo-intimal proliferation resulting in hemodynamic disturbance. The aim of this study was to evaluate a newly developed sheet made from a combination of silk fibroin (SF) and a synthetic polymer, thermoplastic polyurethane (TPU), for surgical use.

Methods

The hybrid SF/TPU sheet was a non-woven fabric with nanofibers that was made using the electrospinning method. The mechanical properties of the SF/TPU sheet were characterized. To determine its biocompatibility, part of the wall of the canine descending aorta was replaced with a SF/TPU sheet as a patch. The patches were removed after 3 months and a histological examination was performed.

Results

The flexibility, water permeability, and suture retention strength of the SF/TPU sheet were excellent and equivalent to those of existing sheets. The SF/TPU sheet had excellent handling properties and fit well into the vascular wall without needle hole bleeding. The histological examination revealed that the intimal tissue was restored well over the intraluminal surface of the explanted SF/TPU sheet, the absence of calcium deposition, and minimal inflammatory reaction, without signs of degradation.

Conclusion

The SF/TPU sheet had excellent mechanical properties and tissue biocompatibility. These favorable features and possible biodegradability of the SF portion warrant a long-term follow-up study.

Keywords

Silk fibroin Polyurethane Electrospinning Surgical sheet Cardiovascular surgery 
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Notes

Acknowledgements

We would like to express our sincere gratitude to Ms. Atsuko Ueda and to Ms. Madoka Omura for their careful management and surgery of the animal experiments in this study. This work is supported by a Scientific technique research promotion program of agriculture, forestry, fishery and food industry (26051A) from the Japanese Ministry of Agriculture, Forestry and Fisheries and a Grant-in-aid for Scientific Research (KAKENHI: 26462094 and 15H03020) from the Japanese Ministry of Education, Culture, Sports, Science and Technology Japan.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest in association with the present study.

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Copyright information

© Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  • Ryo Shimada
    • 1
  • Hayato Konishi
    • 1
  • Hideki Ozawa
    • 1
  • Takahiro Katsumata
    • 1
  • Ryou Tanaka
    • 2
  • Yasumoto Nakazawa
    • 3
  • Shintaro Nemoto
    • 1
  1. 1.Department of Thoracic and Cardiovascular SurgeryOsaka Medical CollegeTakatsukiJapan
  2. 2.Department of Surgery and Veterinary MedicineTokyo University of Agriculture and TechnologyKoganeiJapan
  3. 3.Department of Biotechnology and Life ScienceTokyo University of Agriculture and TechnologyKoganeiJapan

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