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Surgery Today

, Volume 48, Issue 4, pp 422–430 | Cite as

Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio for complete resection of thymoma

  • Masahiro YanagiyaEmail author
  • Jun-ichi Nitadori
  • Kazuhiro Nagayama
  • Masaki Anraku
  • Masaaki Sato
  • Jun Nakajima
Original Article

Abstract

Purpose

The preoperative peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with a poor prognosis for various cancers. We evaluated the prognostic role of the preoperative NLR in patients with thymoma.

Methods

We reviewed the medical records of 254 patients who underwent resection of thymic epithelial tumors at our institution. Patients were excluded if they had received steroid therapy, neoadjuvant therapy, or incomplete resection, or if they had thymic carcinoma or Good’s syndrome, recurrence of thymoma, or missing data. The NLR was measured preoperatively, and outcomes of patients with a low (< 1.96) vs those with a high (≥ 1.96) NLR were compared statistically.

Results

Of 159 eligible patients, 59 (37.1%) had a high NLR and 100 (62.9%) had a low NLR. Overall survival (OS), recurrence-free survival (RFS), disease-specific survival (DSS), disease-related survival (DRS), and the cumulative incidence of recurrence (CIR) differed significantly between the groups. Multivariate analyses revealed that a high NLR was independently associated with disease-related survival and a cumulative incidence of recurrence. A high NLR was also associated with a higher risk of recurrence of Masaoka stage I or II thymoma.

Conclusions

An elevated preoperative NLR was associated with poor outcomes after thymoma resection. Thus, the NLR may be a useful biomarker of the postoperative prognosis of thymoma.

Keywords

Thymoma Surgery Prognosis Thymectomy Neutrophil-to-lymphocyte ratio 

Notes

Acknowledgements

Drs. Yanagiya and Nitadori planned the study and analyzed the data. Dr. Yanagiya wrote the manuscript. Drs. Nagayama, Anraku, and Sato supervised the study. Professor Nakajima supervised the study and edited the manuscript. All authors approved the final version of the submitted manuscript.

Compliance with ethical standards

Funding statement

None.

Conflict of interest

None declared.

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Copyright information

© Springer Japan KK 2017

Authors and Affiliations

  • Masahiro Yanagiya
    • 1
    Email author
  • Jun-ichi Nitadori
    • 1
  • Kazuhiro Nagayama
    • 1
  • Masaki Anraku
    • 1
  • Masaaki Sato
    • 1
  • Jun Nakajima
    • 1
  1. 1.Department of Thoracic SurgeryThe University of Tokyo Graduate School of MedicineTokyoJapan

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