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Surgery Today

, Volume 47, Issue 11, pp 1405–1414 | Cite as

The outcomes of pediatric liver retransplantation from a living donor: a 17-year single-center experience

  • Kohei Miura
  • Seisuke SakamotoEmail author
  • Keita Shimata
  • Masaki Honda
  • Takashi Kobayashi
  • Toshifumi Wakai
  • Yasuhiko Sugawara
  • Yukihiro Inomata
Original Article
  • 271 Downloads

Abstract

Purpose

Liver retransplantation is the only therapeutic option for patients with graft failure after liver transplantation. The aim of this study is to evaluate the outcomes of pediatric retransplantation from living donor at a single center.

Methods

Between December 1998 to August 2015, retransplantation from a living donor was performed for 14 children (<18 years of age) at Kumamoto University Hospital. The characteristics of the retransplantation recipient and the clinicopathological factors between primary transplantation and retransplantation were analyzed to detect the prognostic factors.

Results

In retransplantation, the operative time was longer and the amount of blood loss was greater in comparison to primary transplantation. The 1-, 3-, and 5-year survival rates from the date of retransplantation were 85.7, 85.7, and 78.6%, respectively. The rates of re-laparotomy after primary transplantation, bile leakage and postoperative bleeding after retransplantation were higher than after primary transplantation. Among the three patients who died after retransplantation, the operative time, the rate of re-laparotomy after primary transplantation and the incidence of gastrointestinal complications were higher in comparison to the surviving patients.

Conclusion

Pediatric retransplantation from a living donor is an acceptable procedure that could save the lives of recipients with failing allografts when organs from deceased donors are scarce. To ensure good results, it is essential to make an appropriate assessment of the cardiopulmonary function and the infectious state of the patients before Re-LDLT.

Keywords

Pediatric Living donor Liver transplantation Retransplantation 

Notes

Author contribution

Kohei Miura primarily designed the study, analyzed data, and wrote the manuscript. Keita Shimata, Masaki Honda, and Takashi Kobayashi analyzed data. Seisuke Sakamoto, Toshifumi Wakai, Yasuhiko Sugawara, and Yukihiro Inomata designed the study, analyzed data, and wrote this manuscript. Seisuke Sakamoto is the corresponding author.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest in association with the present study.

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Copyright information

© Springer Japan 2017

Authors and Affiliations

  • Kohei Miura
    • 1
    • 2
  • Seisuke Sakamoto
    • 1
    Email author
  • Keita Shimata
    • 1
  • Masaki Honda
    • 1
  • Takashi Kobayashi
    • 2
  • Toshifumi Wakai
    • 2
  • Yasuhiko Sugawara
    • 1
  • Yukihiro Inomata
    • 1
  1. 1.Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical ScienceKumamoto UniversityKumamotoJapan
  2. 2.Division of Digestive and General SurgeryNiigata University Graduate School of Medical and Dental SciencesNiigataJapan

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