Surgery Today

, Volume 47, Issue 1, pp 27–34 | Cite as

Outcomes of lung cancer surgery in patients with coronary artery disease: a decade of experience at a single institution

  • Ryu Kanzaki
  • Masayoshi Inoue
  • Masato Minami
  • Yasushi Shintani
  • Soichiro Funaki
  • Tomohiro Kawamura
  • Meinoshin Okumura
Original Article



The aim of this study is to investigate the surgical outcomes of surgery for non-small cell lung cancer (NSCLC) in patients with coronary artery disease (CAD).


Among 805 patients who underwent surgery for NSCLC at our hospital within a recent 10-year period, 43 (5.3 %) had a history of CAD. We analyzed the surgical outcomes and risk factors for postoperative complications in these 43 patients.


The postoperative mortality and morbidity rates were 2 and 42 %, respectively. The morbidity rate was significantly higher in the patients with CAD than in those without CAD (P < 0.01). Postoperative cerebrovascular or cardiovascular events occurred in four patients (9 %). Having two of the following was significantly associated with the development of postoperative complications: decreased cardiac function, respiratory dysfunction, or deteriorated renal function (p = 0.04). The 5-year overall and disease-free survival rates of the patients with CAD were 75.6 and 64.5 %, respectively; comparable with those of the patients without CAD; at 77.9 % and 72.5 %, respectively (p = 0.46 and 0.69).


Patients with NSCLC and a history of CAD are at higher risk of complications after pulmonary resection. Combined decreased organ function is a risk factor for postoperative complications. CAD did not influence the long-term outcomes of patients after pulmonary resection for NSCLC.


Lung cancer Coronary artery disease Surgery Comorbidity 


Compliance with ethical standards

Conflict of interest

Ryu Kanzaki and his co-authors have no conflicts of interest to declare.


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Copyright information

© Springer Japan 2016

Authors and Affiliations

  • Ryu Kanzaki
    • 1
  • Masayoshi Inoue
    • 1
  • Masato Minami
    • 1
  • Yasushi Shintani
    • 1
  • Soichiro Funaki
    • 1
  • Tomohiro Kawamura
    • 1
  • Meinoshin Okumura
    • 1
  1. 1.Department of General Thoracic SurgeryOsaka University Graduate School of MedicineSuitaJapan

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