Surgery Today

, Volume 44, Issue 11, pp 2131–2137 | Cite as

Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy

  • Masaru Koizumi
  • Yoshinori Hosoya
  • Katsuya Dezaki
  • Toshihiko Yada
  • Hiroshi Hosoda
  • Kenji Kangawa
  • Hideo Nagai
  • Alan T. Lefor
  • Naohiro Sata
  • Yoshikazu Yasuda
Original Article



Ghrelin may lead to weight gain by appetite stimulation. This prospective study investigated the association between weight loss and the ghrelin levels in patients after gastrectomy.


Thirty-three males and eight females were enrolled in the study. The average age was 66 years. Measurements of the serum ghrelin level and an appetite questionnaire were performed preoperatively and at one, three, six and 12 months postoperatively.


The preoperative serum total ghrelin level was 51.6 ± 31.9 (fmol/ml ± SD), and that at one, three, six and 12 months postoperatively was 16.9 ± 9.0, 21.2 ± 16.0, 28.0 ± 19.1 and 29.6 ± 20.6 (fmol/ml ± SD), respectively. The appetite score was 2.02 ± 1.09 points at 1 month, and increased significantly to 2.61 ± 1.00 by 12 months.


The ghrelin levels were reduced after gastrectomy and did not recover by 12 months postoperatively. Further studies are needed to evaluate these results as the basis of a therapeutic trial.


Ghrelin Gastrectomy Weight loss 


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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Masaru Koizumi
    • 1
    • 2
  • Yoshinori Hosoya
    • 1
  • Katsuya Dezaki
    • 2
  • Toshihiko Yada
    • 2
  • Hiroshi Hosoda
    • 3
  • Kenji Kangawa
    • 3
  • Hideo Nagai
    • 1
    • 4
  • Alan T. Lefor
    • 1
  • Naohiro Sata
    • 1
  • Yoshikazu Yasuda
    • 1
  1. 1.Department of SurgeryJichi Medical University School of MedicineShimotsukeJapan
  2. 2.Division of Integrative Physiology, Department of PhysiologyJichi Medical University School of MedicineShimotsukeJapan
  3. 3.Department of BiochemistryNational Cardiovascular Center Research InstituteOsakaJapan
  4. 4.Department of SurgeryIbaraki Prefectural Central HospitalIbarakiJapan

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