Surgery Today

, Volume 45, Issue 3, pp 259–270 | Cite as

The impact of aging on morbidity and mortality after liver resection: a systematic review and meta-analysis

  • Toru MizuguchiEmail author
  • Masaki Kawamoto
  • Makoto Meguro
  • Kenji Okita
  • Shigenori Ota
  • Masayuki Ishii
  • Tomomi Ueki
  • Toshihiko Nishidate
  • Yasutoshi Kimura
  • Tomohisa Furuhata
  • Koichi Hirata
Review Article


Surgery involving elderly patients is becoming increasingly common due to the rapid aging of societies all over the world. The objective of this study was to elucidate the prognostic differences between elderly and young patients who undergo liver resection. A systematic review based on the PRISMA flow diagram was conducted. Ovid Medline and PubMed were used to search for relevant literature published between January 2000 and March 2013, and the modified MINORS score was used to assess the methodological quality. In cases of hepatocellular carcinoma and miscellaneous liver tumors, the morbidity and mortality rate did not differ significantly between the elderly and young patients. For patients with colorectal metastatic liver cancer, the mortality of the young patients was 2.7 times lower than that of elderly patients. Our review of high-quality retrospective studies was able to elucidate the clinical risks of age on the outcomes after liver surgery in specific patient populations.


Aged patients Elderly patients Liver resection Morbidity Mortality 



This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, No. 23591993 to T. Mizuguchi.


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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Toru Mizuguchi
    • 1
    Email author
  • Masaki Kawamoto
    • 1
  • Makoto Meguro
    • 1
  • Kenji Okita
    • 1
  • Shigenori Ota
    • 1
  • Masayuki Ishii
    • 1
  • Tomomi Ueki
    • 1
  • Toshihiko Nishidate
    • 1
  • Yasutoshi Kimura
    • 1
  • Tomohisa Furuhata
    • 1
  • Koichi Hirata
    • 1
  1. 1.Department of Surgery I, Sapporo Medical University School of Medicine, Sapporo Medical University HospitalSapporo Medical UniversitySapporoJapan

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