Surgery Today

, Volume 44, Issue 5, pp 797–803 | Cite as

Colorectal cancer and hypercoagulability

  • Kazushige Kawai
  • Toshiaki WatanabeEmail author
Review Article


Since the first report of the spontaneous appearance of venous thrombophlebitis as a sign of visceral cancer by Trousseau in 1865, many other studies have documented the existence of cancer-associated coagulation disorders. In this review, we describe the hypercoagulable state associated with colorectal cancer, from three perspectives: first, the incidence, risk factors and prevention of clinically symptomatic thromboembolic conditions associated with cancer, such as venous thromboembolism and arterial thrombosis; second, the association between hypercoagulable conditions, such as thrombocytosis, hyperfibrinogenemia, or d-dimer elevation, and the clinical progression and poor prognosis of cancer patients; third, the experimental approach to elucidate the role of various coagulation-related factors in the process of cancer progression, focusing specifically on the role of platelets and tissue factors.


Hypercoagulability Colorectal cancer Platelets Fibrinogen d-dimer 


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  1. 1.Department of Surgical Oncology, Faculty of MedicineThe University of TokyoTokyoJapan

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