Surgery Today

, Volume 44, Issue 7, pp 1350–1354 | Cite as

Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case

  • Sae MurakamiEmail author
  • Tetsuo Ajiki
  • Kimihiko Ueno
  • Hidehiro Sawa
  • Shinobu Tsuchida
  • Izuru Otsubo
  • Yuko Yoshida
  • Kenta Shinozaki
  • Taro Okazaki
  • Ippei Matsumoto
  • Takumi Fukumoto
  • Yonson Ku
Case Report


A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent curative resection involving extended left hepatectomy and segmental portal vein resection. The pathological findings demonstrated a well-differentiated tubular adenocarcinoma of the bile duct with regional lymph node metastasis (stage IIIB according to the UICC TNM classification), as well as the overexpression of p53 proteins and the K-ras gene mutation in tumor cells. The patient has shown no evidence of recurrence in the 10 months since the operation. Although there are several reports of relatively young adults with cholangiocarcinoma, the majority of such patients demonstrate either an anomalous arrangement of the pancreaticobiliary duct system or primary sclerosing cholangitis. The absence of any morphological abnormalities in this patient’s biliary system implicates de novo carcinogenesis as the most likely cause of the cholangiocarcinoma.


Hilar cholangiocarcinoma Young adults Anomalous arrangement of the pancreaticobiliary duct system 


Conflicts of interest

None of the authors have any conflicts of interest to disclose.


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Sae Murakami
    • 1
    Email author
  • Tetsuo Ajiki
    • 1
  • Kimihiko Ueno
    • 1
  • Hidehiro Sawa
    • 1
  • Shinobu Tsuchida
    • 1
  • Izuru Otsubo
    • 1
  • Yuko Yoshida
    • 1
  • Kenta Shinozaki
    • 1
  • Taro Okazaki
    • 1
  • Ippei Matsumoto
    • 1
  • Takumi Fukumoto
    • 1
  • Yonson Ku
    • 1
  1. 1.Division of Hepato-Biliary-Pancreatic Surgery, Department of SurgeryKobe University Graduate School of MedicineKobeJapan

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