Surgery Today

, Volume 43, Issue 8, pp 930–936 | Cite as

Sclerosing angiomatoid nodular transformation of the spleen related to IgG4-associated disease: report of a case

  • Ho-Hyun Kim
  • Young-Hoe Hur
  • Yang-Seok Koh
  • Jung-Chul Kim
  • Hyun-Jong Kim
  • Jin-Woong Kim
  • Young Kim
  • Jae-Hyuk Lee
  • Chol-Kyoon Cho
Case Report

Abstract

Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular mass, with fewer than 100 cases documented. It is generally recognized as a vascular lesion that develops in the red pulp of the spleen; however, its pathogenesis is not clearly defined. We report a case of SANT of the spleen, which presents evidence to support the hypothesis that this disease entity is associated with IgG4-associated disease. Microscopically, the tumor was composed of multiple vascular structures separated by fibrous connective tissue and immunohistochemical examination revealed positive staining for CD31, CD34, factor VIII, and IgG4. Further research based on large number of cases is warranted to clarify the pathogenesis of this tumor.

Keywords

Sclerosing angiomatoid nodular transformation Spleen IgG4-associated disease Immunohistochemistry 

Notes

Conflict of interest

None of authors have a conflict of interest or have received financial support.

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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Ho-Hyun Kim
    • 1
  • Young-Hoe Hur
    • 1
  • Yang-Seok Koh
    • 1
  • Jung-Chul Kim
    • 1
  • Hyun-Jong Kim
    • 1
  • Jin-Woong Kim
    • 2
  • Young Kim
    • 3
  • Jae-Hyuk Lee
    • 3
  • Chol-Kyoon Cho
    • 1
  1. 1.Department of SurgeryChonnam National University Medical SchoolGwangjuKorea
  2. 2.Department of RadiologyChonnam National University Medical SchoolGwangjuKorea
  3. 3.Department of PathologyChonnam National University Medical SchoolGwangjuKorea

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